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IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
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IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
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Journal Article
IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge
2010
Overview
Staphylococcus aureus is the most frequent cause of bacteremia and hospital-acquired infection, however a vaccine that prevents staphylococcal disease is currently not available. Two sortase-anchored surface proteins, IsdA and IsdB, have been identified as subunit vaccines that, following active immunization, protect experimental animals against intravenous challenge with staphylococci. Here we investigate the molecular basis of this immunity and report that, when passively transferred to naïve mice, purified antibodies directed against IsdA or IsdB protected against staphylococcal abscess formation and lethal intravenous challenge. When added to mouse blood, IsdA- or IsdB-specific antibodies did not promote rapid opsonophagocytic killing of wild-type staphylococci. Antibodies directed against IsdA interfered with heme-binding and IsdB antibodies perturbed the ability of this surface protein to bind hemoglobin. As the structural genes for
isdA and
isdB are required for heme-iron scavenging during the pathogenesis of infection, we hypothesize that IsdA and IsdB antibodies may at least in part provide protection against staphylococci by interfering with the pathogen's heme-iron scavenging mechanisms.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Animals
/ Antibodies, Bacterial - immunology
/ Antigens, Bacterial - genetics
/ Antigens, Bacterial - immunology
/ Biological and medical sciences
/ Cation Transport Proteins - genetics
/ Cation Transport Proteins - immunology
/ Disease
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ IsdA
/ IsdB
/ Mice
/ Mutation
/ Plasmids
/ Proteins
/ Rabbits
/ Staphylococcal Infections - immunology
/ Staphylococcal Infections - prevention & control
/ Studies
/ Vaccine
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
