Asset Details
Do you wish to reserve the book?
Host microbiota constantly control maturation and function of microglia in the CNS
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Host microbiota constantly control maturation and function of microglia in the CNS
Do you wish to request the book?
Host microbiota constantly control maturation and function of microglia in the CNS
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Host microbiota constantly control maturation and function of microglia in the CNS
2015
Overview
In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota complexity displayed defects in microglial cell proportions and maturation, leading to impaired innate immune responses. The authors find that short-chain fatty acid signaling regulates these effects
in vivo
.
As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. We observed substantial contributions of the host microbiota to microglia homeostasis, as germ-free (GF) mice displayed global defects in microglia with altered cell proportions and an immature phenotype, leading to impaired innate immune responses. Temporal eradication of host microbiota severely changed microglia properties. Limited microbiota complexity also resulted in defective microglia. In contrast, recolonization with a complex microbiota partially restored microglia features. We determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermentation products, regulated microglia homeostasis. Accordingly, mice deficient for the SCFA receptor FFAR2 mirrored microglia defects found under GF conditions. These findings suggest that host bacteria vitally regulate microglia maturation and function, whereas microglia impairment can be rectified to some extent by complex microbiota.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 14/63
/ 42/35
/ 42/44
/ 64/110
/ 9/74
/ Analysis
/ Animal Genetics and Genomics
/ Animals
/ Central Nervous System - immunology
/ Central Nervous System - metabolism
/ Central Nervous System - physiology
/ Disease
/ Fatty Acids, Volatile - immunology
/ Fatty Acids, Volatile - metabolism
/ Female
/ Hygiene
/ Immunity, Innate - immunology
/ Immunity, Innate - physiology
/ Male
/ Mice
We currently cannot retrieve any items related to this title. Kindly check back at a later time.