Journal Article

Relationship between adiponectin multimer levels and subtypes of cerebral infarction

Noriko Tagawa, Aya Fujinami, Shigeatsu Natsume, Shigeto Mizuno, Ikuo Kato

2022

Overview

Serum adiponectin levels are decreased in patients with cerebral infarction. Adiponectin in circulation exists in three isoforms: high molecular weight (HMW), medium molecular weight (MMW), and low molecular weight (LMW) adiponectin. We measured serum levels of total adiponectin and adiponectin multimers (HMW, MMW, and LMW) in patients with cerebral infarction and compared the serum levels of the three adiponectin multimers in stroke subtypes. We also evaluated the clinical value of adiponectin multimer levels as a biomarker for cerebral infarction. We assessed a total of 132 patients with cerebral infarctions. The serum levels of total and adiponectin multimers were measured using enzyme-linked immunosorbent assay (ELISA). The total and HMW adiponectin levels were significantly lower in atherothrombotic infarction (AI) than in cerebral embolism (CE) (total, p < 0.05; HMW, p < 0.05). In male patients, the MMW adiponectin level was significantly lower in the lacunar infarction (LI) group than in the AI group (p < 0.05). The LMW adiponectin level was significantly lower in the AI group than in the LI and CE groups (LI, p < 0.001; CE, p = 0.001). However, there were no significant differences in adiponectin multimer levels among the stroke subtypes in female subjects. Additionally, in female patients with AI and LI, the LMW adiponectin levels were negatively associated with C-reactive protein (CRP; AI, p < 0.05; LI, p < 0.05). These findings suggest that a decrease in adiponectin is associated with AI and that serum LMW adiponectin level represents a potential biomarker for AI.

• Publisher: Public Library of Science (PLoS),Public Library of Science
• Subject: Adiponectin / Adiponectin - blood / Adiponectin - metabolism / Aged / Biochemistry / Biology and Life Sciences / Biomarkers / Biomarkers - blood / Biomarkers - metabolism / Body mass index / C-Reactive Protein / C-Reactive Protein - metabolism / Cerebral blood flow / Cerebral Infarction / Cerebral Infarction - blood / Cerebral Infarction - metabolism / Cerebrovascular disease / Cholesterol / Cytokines / Diagnosis / Embolism / Enzyme-linked immunosorbent assay / Female / Health aspects / Humans / Infarction / Isoforms / Kinases / Laboratories / Low molecular weights / Male / Medicine / Medicine and Health Sciences / Metabolic syndrome / Molecular Weight / Overweight / Overweight - blood / Overweight - metabolism / Patients / Pharmaceuticals / Protein Isoforms / Protein Isoforms - blood / Protein Isoforms - metabolism / Q / R / Research and Analysis Methods / Research Article / Science / Serum levels / Standard deviation / Stroke / Stroke - blood / Stroke - metabolism