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Bacillus and Paenibacillus secreted polyketides and peptides involved in controlling human and plant pathogens
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Bacillus and Paenibacillus secreted polyketides and peptides involved in controlling human and plant pathogens
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Journal Article
Bacillus and Paenibacillus secreted polyketides and peptides involved in controlling human and plant pathogens
2019
Overview
Overuse of broad-spectrum antibiotics to control human and plant pathogens greatly accelerated the development of antibiotic resistance among bacteria and fungi. Therefore, usage of new approaches is necessary to control outbreaks of phytopathogenic diseases as well as multidrug-resistant human pathogens. Many of the polyketides (PKs) and lipopetides (LPs) produced by
Bacillus
and
Paenibacillus
species have been described as antimicrobial agents that can be potentially applied as sustainable bio-organic products in medicine against human pathogens and in agriculture for controlling plant pathogens. The present review provides a general information about the classification and biochemical structure of known
Bacillus-
and
Paenibacillus
-secreted PKs, as well as ribosomally and nonribosomally synthesized peptides, their functional features, gene clusters involved in their production, and the mode of action of these metabolites.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V,Springer Verlag
Subject
/ Anti-Infective Agents - metabolism
/ Anti-Infective Agents - pharmacology
/ Bacillus
/ Bacteria
/ Biological Control Agents - metabolism
/ Biological Control Agents - pharmacology
/ Biomedical and Life Sciences
/ Control
/ Drug Resistance, Multiple, Bacterial
/ Enzymes
/ Fungi
/ Genes
/ Humans
/ medicine
/ Microbial Genetics and Genomics
/ Microbiology and Parasitology
/ Peptides
/ Plant Diseases - prevention & control
/ Plants
