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Changes in Effective Connectivity by Propofol Sedation
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Journal Article
Changes in Effective Connectivity by Propofol Sedation
2013
Overview
Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Anesthetics, Intravenous - administration & dosage
/ Auditory Cortex - drug effects
/ Auditory Cortex - physiology
/ Auditory Perception - physiology
/ Biology
/ Female
/ Functional magnetic resonance imaging
/ Humans
/ Male
/ Medicine
/ Narcotics - administration & dosage
/ Neural Pathways - drug effects
/ Neural Pathways - physiology
/ NMR
/ Phenols (Class of compounds)
/ Propofol
/ Propofol - administration & dosage
/ Science
