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Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival
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Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival
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Journal Article
Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival
2022
Overview
Background
Letrozole has been reported to be effective in treating anovulation, preventing ovarian hyperstimulation syndrome (OHSS), and retrieving oocytes in breast cancer patients. However, the role and mechanism of letrozole in follicular development remain unclear.
Results
We treated mouse preantral follicles with various treatments; we found no significant difference in follicle survival rates in the letrozole (LET) group compared with the control group, but the average diameter of follicles in the LET group tended to be larger (CTRL vs. LET 30,
p
= 0.064; CTRL vs. LET 100,
p
= 0.025). The estradiol concentrations in culture media of the LET group were significantly lower than those observed in the control group (CTRL vs. LET 30,
p
= 0.038; CTRL vs. LET 100,
p
= 0.025). We further found a marked increase in follicle-stimulating hormone receptor (FSHR) gene expression in response to letrozole treatment (CTRL vs. LET 30,
p
= 0.075; CTRL vs. LET 100,
p
= 0.034). This result suggested that increased FSHR expression promotes follicle development. Letrozole inhibited aromatase activity, but the effect was limited. Letrozole did not significantly reduce vascular endothelial growth factor (VEGF) gene expression.
Conclusions
Letrozole may promote follicle development by increasing the expression of FSHR. Letrozole may be useful for fertility preservation of patients with estrogen-dependent cancers such as breast cancer and various other cancers. Whether letrozole has a direct effect in reducing OHSS requires further investigation.
Publisher
Springer Science and Business Media LLC,BioMed Central,BioMed Central Ltd,BMC
Subject
/ Female
/ Follicle Stimulating Hormone
/ Follicle Stimulating Hormone - metabolism
/ Humans
/ Medicine
/ Mice
/ Ovarian Follicle - metabolism
/ Ovarian Hyperstimulation Syndrome
/ ovarian hyperstimulation syndrome (OHSS)
/ Ovarian Hyperstimulation Syndrome - metabolism
/ Phenols
/ polycystic ovary syndrome (PCOS)
/ RG1-991
/ Scientific equipment and supplies industry
/ Vascular endothelial growth factor
