Asset Details
Do you wish to reserve the book?
TMK1-mediated auxin signalling regulates differential growth of the apical hook
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
TMK1-mediated auxin signalling regulates differential growth of the apical hook
Do you wish to request the book?
TMK1-mediated auxin signalling regulates differential growth of the apical hook
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
TMK1-mediated auxin signalling regulates differential growth of the apical hook
2019
Overview
The plant hormone auxin has crucial roles in almost all aspects of plant growth and development. Concentrations of auxin vary across different tissues, mediating distinct developmental outcomes and contributing to the functional diversity of auxin. However, the mechanisms that underlie these activities are poorly understood. Here we identify an auxin signalling mechanism, which acts in parallel to the canonical auxin pathway based on the transport inhibitor response1 (TIR1) and other auxin receptor F-box (AFB) family proteins (TIR1/AFB receptors)
1
,
2
, that translates levels of cellular auxin to mediate differential growth during apical-hook development. This signalling mechanism operates at the concave side of the apical hook, and involves auxin-mediated C-terminal cleavage of transmembrane kinase 1 (TMK1). The cytosolic and nucleus-translocated C terminus of TMK1 specifically interacts with and phosphorylates two non-canonical transcriptional repressors of the auxin or indole-3-acetic acid (Aux/IAA) family (IAA32 and IAA34), thereby regulating ARF transcription factors. In contrast to the degradation of Aux/IAA transcriptional repressors in the canonical pathway, the newly identified mechanism stabilizes the non-canonical IAA32 and IAA34 transcriptional repressors to regulate gene expression and ultimately inhibit growth. The auxin–TMK1 signalling pathway originates at the cell surface, is triggered by high levels of auxin and shares a partially overlapping set of transcription factors with the TIR1/AFB signalling pathway. This allows distinct interpretations of different concentrations of cellular auxin, and thus enables this versatile signalling molecule to mediate complex developmental outcomes.
In
Arabidopsis thaliana
, a newly identified auxin signalling pathway that involves TMK1 protein cleavage and IAA32 and IAA34 transcriptional repressors mediates complex developmental outcomes by allowing distinct interpretations of varying concentrations of cellular auxin.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/44
/ 13/51
/ 14/19
/ 14/34
/ 14/63
/ 38/91
/ 45/23
/ 82/58
/ Arabidopsis - growth & development
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Auxins
/ Cellular signal transduction
/ Defects
/ Genomes
/ Growth
/ Hormones
/ Humanities and Social Sciences
/ Indoleacetic Acids - antagonists & inhibitors
/ Indoleacetic Acids - metabolism
/ Kinases
/ Letter
/ Mutation
/ Plant Growth Regulators - antagonists & inhibitors
/ Plant Growth Regulators - metabolism
/ Protein-Serine-Threonine Kinases - genetics
/ Protein-Serine-Threonine Kinases - metabolism
/ Proteins
/ Receptors, Cell Surface - metabolism
/ Repressor Proteins - genetics
/ Repressor Proteins - metabolism
/ Science
