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Exploration of transcriptional regulation network between buffalo oocytes and granulosa cells and its impact on different diameter follicles
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Exploration of transcriptional regulation network between buffalo oocytes and granulosa cells and its impact on different diameter follicles
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Journal Article
Exploration of transcriptional regulation network between buffalo oocytes and granulosa cells and its impact on different diameter follicles
2024
Overview
Background
Buffalo is a globally important livestock species, but its reproductive performance is relatively low than cattles. At present, dominant follicle development specific process and mechanistic role of follicular growth related genes in water buffaloes are not well understood. Therefore, we comprehensively performed transcriptomics of granulosa cells and oocytes from different-sized follicles in water buffalo to identify key candidate genes that influence follicle development and diameter, and further explored the potential regulatory mechanisms of granulosa cells and oocytes in the process of water buffalo follicle development.
Results
In this study, we found918 granulosa cell transcripts and 1401 oocyte transcripts were correlated in follicles of different diameters, and the expression differences were significant. Subsequent enrichment analysis of the co-expressed differentially expressed transcripts identified several genes targeted by long non-coding RNAs (lncRNAs) and associated with follicular development. Notably, the upregulation of
BUB1
regulated by
MSTRG.41325.4
and interactive action of
SMAD2
and
SMAD7
might have key regulatory role in follicular development. Additionally, we also detected key differentially expressed genes that potentially influence follicular hormone metabolism and growth, like
ID2
,
CHRD
,
TGIF2
and
MAD2L1
, and constructed an interaction network between lncRNA transcripts and mRNAs.
Conclusions
In summary, this study preliminarily revealed the differences in gene expression patterns among buffalo follicles of different sizes and their potential molecular regulatory mechanisms. It provides a new perspective for exploring the mechanism of buffalo follicular dominance and improving buffalo reproductive performance.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biomedical and Life Sciences
/ Buffalo
/ Different diameter follicles
/ Estrone
/ Female
/ Genes
/ Granulosa Cells - metabolism
/ Microbial Genetics and Genomics
/ Oocytes
/ Ovarian Follicle - metabolism
/ Ovaries
/ Regulatory mechanisms (biology)
/ RNA, Long Noncoding - genetics
/ RNA, Long Noncoding - metabolism
/ Software
/ Transcriptional coactivators
/ Water
