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Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
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Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
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Journal Article
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
2012
Overview
Cultured human pluripotent stem cells can be differentiated to immature pancreatic beta cells, but no one has yet succeeded in maturing these cells
in vitro
. Blum
et al
. define markers of beta-cell maturation that can be used to screen conditions for generating fully functional beta cells.
Insulin-expressing cells that have been differentiated from human pluripotent stem cells
in vitro
lack the glucose responsiveness characteristic of mature beta cells. Beta-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide beta cells
in vitro
. We find that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Dextrose
/ Fundamental and applied biological sciences. Psychology
/ Glucose
/ Health. Pharmaceutical industry
/ Humans
/ Industrial applications and implications. Economical aspects
/ Insulin
/ Insulin-Secreting Cells - cytology
/ Insulin-Secreting Cells - metabolism
/ Mice
