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Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus
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Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus
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Journal Article
Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus
2016
Overview
Depression is a common debilitating human disease whose etiology has defied decades of research. A critical bottleneck is the difficulty in modeling depressive episodes in animals. Here, we show that a transgenic mouse with chronic forebrain expression of a dominant negative mutant of
Polg1
, a mitochondrial DNA (mtDNA) polymerase, exhibits lethargic behavioral changes, which are associated with emotional, vegetative and psychomotor disturbances, and response to antidepression drug treatment. The results suggested a symptomatic similarity between the lethargic behavioral change that was recurrently and spontaneously experienced by the mutant mice and major depressive episode as defined by DSM-5. A comprehensive screen of mutant brain revealed a hotspot for mtDNA deletions and mitochondrial dysfunction in the paraventricular thalamic nucleus (PVT) with similar defects observed in postmortem brains of patients with mitochondrial disease with mood symptoms. Remarkably, the genetic inhibition of PVT synaptic output by Cre-loxP-dependent expression of tetanus toxin triggered
de novo
depression-like episodes. These findings identify a novel preclinical mouse model and brain area for major depressive episodes with mitochondrial dysfunction as its cellular mechanism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 42/44
/ 45/77
/ 631/378
/ 64/110
/ Analysis
/ Animals
/ Complications and side effects
/ Depressive Disorder - complications
/ Depressive Disorder - genetics
/ Depressive Disorder - pathology
/ Depressive Disorder - physiopathology
/ Disease
/ DNA-Directed DNA Polymerase - genetics
/ DNA-Directed DNA Polymerase - metabolism
/ Female
/ Humans
/ Male
/ Medicine
/ Midline Thalamic Nuclei - metabolism
/ Midline Thalamic Nuclei - pathology
/ Mutation
/ Ophthalmoplegia, Chronic Progressive External - complications
/ Ophthalmoplegia, Chronic Progressive External - metabolism
/ Ophthalmoplegia, Chronic Progressive External - pathology
/ Tetanus
