Asset Details
Do you wish to reserve the book?
MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
Do you wish to request the book?
MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
2017
Overview
Background
Cervical cancer is the second leading cause of death among female patients with cancer in the world. High risk human papillomavirus has causal roles in cervical cancer initiation and progression by deregulating several cellular processes. However, HPV infection is not sufficient for cervical carcinoma development. Therefore, other genetic and epigenetic factors may be involved in this complex disease, and the identification of which may lead to better diagnosis and treatment. Our aim was to analyze the expression of microRNAs in cervical cancer cases positive or negative for HPV E6/E7 mRNA, and to assess their diagnostic usefulness and relevance.
Methods
The expression of three different microRNAs (miR-9, miR-21, and miR-155) in 52 formalin-fixed paraffin-embedded (FFPE) primary cervical cancer tissue samples and 50 FFPE normal cervical tissue samples were evaluated.
Results
MiR-9, miR-21, and miR-155 were significantly overexpressed in cervical cancer tissues compared to normal tissues (
P
< 0.001). MiR-21 and miR-155 expression combined with the HPV E6/E7 mRNA assay in HPV E6/E7 negative cervical cancer showed increased AUC of 0.7267 and 0.7000, respectively (
P
= 0.01,
P
= 0.04), demonstrating their potential as diagnostic tools. Moreover, miR-21 and miR-155 were predictors showing a 7 fold and 10.3 fold higher risk for HPV E6/E7 negative patients with cervical cancer (
P
= 0.024 and
P
= 0.017, respectively) while miR-155 was a predictor showing a 27.9 fold higher risk for HPV E6/E7 positive patients with cervical cancer (
P <
0.0001).
Conclusions
There is a strong demand for additional, alternative molecular biomarkers for diagnosis and management of precancer patients. MiR-21 and miR-155 may be helpful in the prediction of both HPV positive and HPV negative cases of cervical cancer.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Biomedical and Life Sciences
/ Carcinoma, Squamous Cell - diagnosis
/ Carcinoma, Squamous Cell - genetics
/ Carcinoma, Squamous Cell - metabolism
/ Carcinoma, Squamous Cell - virology
/ Cervix
/ Complications and side effects
/ Female
/ Health Promotion and Disease Prevention
/ Humans
/ Kinases
/ MicroRNA
/ miRNA
/ mRNA
/ Oncology
/ Papillomavirus E7 Proteins - genetics
/ Papillomavirus E7 Proteins - metabolism
/ Papillomavirus Infections - diagnosis
/ Papillomavirus Infections - genetics
/ Papillomavirus Infections - metabolism
/ Papillomavirus Infections - virology
/ Paraffin
/ RT-qPCR
/ Uterine Cervical Neoplasms - diagnosis
/ Uterine Cervical Neoplasms - genetics
