Asset Details
Do you wish to reserve the book?
Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization
Do you wish to request the book?
Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization
2024
Overview
The skin microbiome maintains healthy human skin, and disruption of the microbiome balance leads to inflammatory skin diseases such as folliculitis and atopic dermatitis. Staphylococcus aureus and Cutibacterium acnes are pathogenic bacteria that simultaneously inhabit the skin and cause inflammatory diseases of the skin through the activation of innate immune responses. Silkworms are useful invertebrate animal models for evaluating innate immune responses. In silkworms, phenoloxidase generates melanin as an indicator of innate immune activation upon the recognition of bacterial or fungal components. We hypothesized that S . aureus and C . acnes interact to increase the innate immunity-activating properties of S . aureus . In the present study, we showed that acidification is involved in the activation of silkworm hemolymph melanization by S . aureus . Autoclaved-killed S . aureus ( S . aureus [AC]) alone does not greatly activate silkworm hemolymph melanization. On the other hand, applying S . aureus [AC] treated with C . acnes culture supernatant increased the silkworm hemolymph melanization. Adding C . acnes culture supernatant to the medium decreased the pH. S . aureus [AC] treated with propionic acid, acetic acid, or lactic acid induced higher silkworm hemolymph melanization activity than untreated S . aureus [AC]. S . aureus [AC] treated with hydrochloric acid also induced silkworm hemolymph melanization. The silkworm hemolymph melanization activity of S . aureus [AC] treated with hydrochloric acid was inhibited by protease treatment of S . aureus [AC]. These results suggest that acid treatment of S . aureus induces innate immune activation in silkworms and that S . aureus proteins are involved in the induction of innate immunity in silkworms.
Publisher
Public Library of Science (PLoS),Public Library of Science
We currently cannot retrieve any items related to this title. Kindly check back at a later time.