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A 54-year-old woman with chronic lithium toxicity
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A 54-year-old woman with chronic lithium toxicity
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Journal Article
A 54-year-old woman with chronic lithium toxicity
2021
Overview
In 2019 in the US, 7,085 toxic lithium exposures were documented. This refers to substantial exposures that may have resulted in a clinical outcome of at least moderate severity. Of these, 22% resulted in serious clinical consequences, including 4 deaths. Lithium has a narrow therapeutic index and a wide range of toxicities. It is an effective and widely prescribed therapy for bipolar disorder and is also used off label for other psychiatric disorders. It is available in both immediate-release and sustained-re lease preparations. The recommended therapeutic range varies with patient age, owing to age-related changes in renal function and increased prevalence of polypharmacy and drug interactions. Lithium is an inorganic monovalent cation with a small molecular weight of 7 Da. It is rapidly absorbed, not protein bound, has a low volume of distribution between 0.6 and 0.9 L/kg, and is freely excreted unchanged via the kidneys. Here, Kobylianskii et al examine the case of 54-year-old woman with chronic lithium toxicity.
Publisher
Elsevier Inc,CMA Joule Inc,CMA Impact, Inc
Subject
/ Antidepressive Agents - administration & dosage
/ Antidepressive Agents - poisoning
/ Bipolar Disorder - drug therapy
/ Coma
/ Complications and side effects
/ Drugs
/ Female
/ Humans
/ Kidneys
/ Lithium
/ Lithium Carbonate - administration & dosage
/ Lithium Carbonate - poisoning
/ Patients
/ Poisons
/ Polyuria
/ Practice
/ Toxicity
/ Urine
