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Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
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Journal Article
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
2018
Overview
Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease. Unraveling the genetic background for the regional vulnerability of these proteinopathies can help in understanding the mechanisms of pathology progression. To that end, we developed a novel graph theory approach and used it to investigate the intersection of longitudinal Aβ and tau positron emission tomography imaging of healthy adult individuals and the genetic transcriptome of the Allen Human Brain Atlas. We identified distinctive pathways for tau and Aβ accumulation, of which the tau pathways correlated with cognitive levels. We found that tau propagation and Aβ propagation patterns were associated with a common genetic profile related to lipid metabolism, in which
APOE
played a central role, whereas the tau-specific genetic profile was classified as ‘axon related’ and the Aβ profile as ‘dendrite related’. This study reveals distinct genetic profiles that may confer vulnerability to tau and Aβ in vivo propagation in the human brain.
Cross-sectional and longitudinal PET imaging of amyloid beta and tau in the human brain is combined with gene expression profiles to define the interactions between Alzheimer’s disease-related pathology propagation and brain-region-specific vulnerability.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Alzheimer Disease - diagnostic imaging
/ Alzheimer Disease - genetics
/ Alzheimer Disease - metabolism
/ Alzheimer Disease - pathology
/ Amyloid beta-Peptides - genetics
/ Amyloid beta-Peptides - metabolism
/ Analysis
/ Biomedical and Life Sciences
/ Brain
/ Cerebral Cortex - diagnostic imaging
/ Female
/ Genes
/ Humans
/ Lipids
/ Male
/ Neurons
/ Positron emission tomography
/ Protein Aggregation, Pathological - diagnostic imaging
/ Protein Aggregation, Pathological - genetics
/ Protein Aggregation, Pathological - pathology
/ Proteins
