Asset Details
Do you wish to reserve the book?
Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
Do you wish to request the book?
Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly
2021
Overview
Background
Akkermansia muciniphila
is a human gut microbe with a key role in the physiology of the intestinal mucus layer and reported associations with decreased body mass and increased gut barrier function and health. Despite its biomedical relevance, the genomic diversity of
A. muciniphila
remains understudied and that of closely related species, except for
A. glycaniphila
, unexplored.
Results
We present a large-scale population genomics analysis of the
Akkermansia
genus using 188 isolate genomes and 2226 genomes assembled from 18,600 metagenomes from humans and other animals. While we do not detect
A. glycaniphila
, the
Akkermansia
strains in the human gut can be grouped into five distinct candidate species, including
A. muciniphila
, that show remarkable whole-genome divergence despite surprisingly similar 16S rRNA gene sequences. These candidate species are likely human-specific, as they are detected in mice and non-human primates almost exclusively when kept in captivity. In humans,
Akkermansia
candidate species display ecological co-exclusion, diversified functional capabilities, and distinct patterns of associations with host body mass. Analysis of CRISPR-Cas loci reveals new variants and spacers targeting newly discovered putative bacteriophages. Remarkably, we observe an increased relative abundance of
Akkermansia
when cognate predicted bacteriophages are present, suggesting ecological interactions.
A. muciniphila
further exhibits subspecies-level genetic stratification with associated functional differences such as a putative exo/lipopolysaccharide operon.
Conclusions
We uncover a large phylogenetic and functional diversity of the
Akkermansia
genus in humans. This variability should be considered in the ongoing experimental and metagenomic efforts to characterize the health-associated properties of
A. muciniphila
and related bacteria.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Akkermansia - classification
/ Animal Genetics and Genomics
/ Animals
/ Bacteriophages - growth & development
/ Biomedical and Life Sciences
/ Clustered Regularly Interspaced Short Palindromic Repeats
/ CRISPR
/ Datasets
/ Gastrointestinal Microbiome - genetics
/ Genes
/ Genomes
/ Genomics
/ genus
/ Humans
/ Metadata
/ Mice
/ Microbial Genetics and Genomics
/ mucus
/ Obesity
/ Operon
/ Phages
/ RNA, Ribosomal, 16S - genetics
/ rRNA 16S
/ Species
