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NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression
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NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression
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Journal Article
NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression
2004
Overview
Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Genes preferentially expressed in oocytes, including Oct4 and Gdf9, are down-regulated in$Nobox^{-/-}$mice, whereas ubiquitous genes such as Bmp4, Kit, and Bax remain unaffected. Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ Coding
/ Cysts
/ Embryonic and Fetal Development - genetics
/ Female
/ Females
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Developmental
/ Genes
/ Homeodomain Proteins - genetics
/ Homeodomain Proteins - physiology
/ Male
/ Mammalian female genital system
/ Meiosis
/ Mice
/ Oocytes
/ Ovarian Follicle - physiology
/ Ovaries
/ Rodents
