Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

by Goodnow, Chris C , Allemeersch, Joke , Tian, Lei , Overbergh, Lut , Socha, Luis , Lyssenko, Valeriya , Linterman, Michelle A , Lambrechts, Diether , Liston, Adrian , Carr, Edward J , Petrovsky, Nikolai , Schonefeldt, Susann , Dooley, James , Lesage, Sylvie , Schlenner, Susan M , Jetten, Anton M , Dahlstrom, Jane E , Chabot-Roy, Genevieve , Garcia-Perez, Josselyn E , Delghingaro-Augusto, Viviane , Vandenbussche, Jonathan , Pasciuto, Emanuela , Di Marino, Daniele , Oskolkov, Nikolay , Franckaert, Dean , Nolan, Christopher J , Gevaert, Kris , Laybutt, D Ross , Lagou, Vasiliki

in 14 / 14/1 / 38 / 38/91 / 631/208/2489 / 692/699/2743/137/1418 / 692/699/2743/137/773 / 82/58 / Agriculture / Animal Genetics and Genomics / Animals / Apoptosis / Biomedicine / Cancer Research / Cellular Senescence / Clinical Medicine / Congenital diseases / Consortia / Councils / Defects / Diabetes / Diabetes Mellitus, Type 1 - genetics / Diabetes Mellitus, Type 1 - pathology / Diabetes Mellitus, Type 2 - genetics / Diabetes Mellitus, Type 2 - pathology / Diet / DNA-Binding Proteins - genetics / Endocrinology and Diabetes / Endokrinologi och diabetes / Female / Gene expression / Gene Expression Regulation / Gene Function / Genetic aspects / Genetic diversity / Genetic Predisposition to Disease / Genetic research / Genetic susceptibility / Genetic variation / Health aspects / Human Genetics / Humans / Insulin / Insulin resistance / Insulin-Secreting Cells - pathology / Investigations / Klinisk medicin / Male / Medical and Health Sciences / Medicin och hälsovetenskap / Metabolism / Mice / Mice, Inbred C57BL / Mice, Inbred NOD / Mice, Transgenic / Mutation / Pancreatic beta cells / Protein Folding / Proteins / Repressor Proteins - genetics / Risk factors / Rodents / Sex Factors / Software / Stress, Physiological / Trans-Activators - genetics / Transgenic animals

2016

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

2016

Confirm

Do you wish to request the book?

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

2016

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Goodnow, Chris C,

Allemeersch, Joke,

Tian, Lei,

Overbergh, Lut,

Socha, Luis,

Lyssenko, Valeriya,

Linterman, Michelle A,

Lambrechts, Diether,

Liston, Adrian,

Carr, Edward J,

Petrovsky, Nikolai,

Schonefeldt, Susann,

Dooley, James,

Lesage, Sylvie,

Schlenner, Susan M,

Jetten, Anton M,

Dahlstrom, Jane E,

Chabot-Roy, Genevieve,

Garcia-Perez, Josselyn E,

Delghingaro-Augusto, Viviane,

Vandenbussche, Jonathan,

Pasciuto, Emanuela,

Di Marino, Daniele,

Oskolkov, Nikolay,

Franckaert, Dean,

Nolan, Christopher J,

Gevaert, Kris,

Laybutt, D Ross,

Lagou, Vasiliki

2016

Overview

Adrian Liston and colleagues use a transgenic mouse model to demonstrate that beta cell failure is a mechanistic commonality in type 1 and type 2 diabetes. They find that the changes in the molecular pathways identified as contributing to beta cell loss are paralleled in human islets from patients with type 2 diabetes. Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 14/1

/ 38

/ 38/91

/ 631/208/2489

/ 692/699/2743/137/1418

/ 692/699/2743/137/773

/ 82/58