Asset Details
Do you wish to reserve the book?
SimB16: Modeling Induced Immune System Response against B16-Melanoma
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
SimB16: Modeling Induced Immune System Response against B16-Melanoma
Do you wish to request the book?
SimB16: Modeling Induced Immune System Response against B16-Melanoma
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
SimB16: Modeling Induced Immune System Response against B16-Melanoma
2011
Overview
Immunological therapy of progressive tumors requires not only activation and expansion of tumor specific cytotoxic T lymphocytes (CTLs), but also an efficient effector phase including migration of CTLs in the tumor tissue followed by conjugation and killing of target cells. We report the application of an agent-based model to recapitulate both the effect of a specific immunotherapy strategy against B16-melanoma in mice and the tumor progression in a generic tissue section. A comparison of the in silico results with the in vivo experiments shows excellent agreement. We therefore use the model to predict a critical role for CD137 expression on tumor vessel endothelium for successful therapy and other mechanistic aspects. Experimental results are fully compatible with the model predictions. The biologically oriented in silico model derived in this work will be used to predict treatment failure or success in other pre-clinical conditions eventually leading new promising in vivo experiments.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Antigens
/ Biology
/ Endothelial Cells - immunology
/ Endothelial Cells - metabolism
/ Female
/ HIV
/ Human immunodeficiency virus
/ Melanoma
/ Melanoma, Experimental - immunology
/ Melanoma, Experimental - metabolism
/ Melanoma, Experimental - pathology
/ Melanoma, Experimental - therapy
/ Mice
/ Ontology
/ T cells
/ T-Lymphocytes, Cytotoxic - immunology
/ Therapy
/ Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism
/ Tumors
