Asset Details
Do you wish to reserve the book?
Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli
Do you wish to request the book?
Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli
2015
Overview
Although central serotonergic systems are known to influence responses to noxious stimuli, mechanisms underlying serotonergic modulation of pain responses are unclear. We proposed that serotonin 2C receptors (5-HT2CRs), which are expressed within brain regions implicated in sensory and affective responses to pain, contribute to the serotonergic modulation of pain responses. In mice constitutively lacking 5-HT2CRs (2CKO mice) we found normal baseline sensory responses to noxious thermal, mechanical and chemical stimuli. In contrast, 2CKO mice exhibited a selective enhancement of affect-related ultrasonic afterdischarge vocalizations in response to footshock. Enhanced affect-related responses to noxious stimuli were also exhibited by 2CKO mice in a fear-sensitized startle assay. The extent to which a brief series of unconditioned footshocks produced enhancement of acoustic startle responses was markedly increased in 2CKO mice. As mesolimbic dopamine pathways influence affective responses to noxious stimuli, and these pathways are disinhibited in 2CKO mice, we examined the sensitivity of footshock-induced enhancement of startle to dopamine receptor blockade. Systemic administration of the dopamine D2/D3 receptor antagonist raclopride selectively reduced footshock-induced enhancement of startle without influencing baseline acoustic startle responses. We propose that 5-HT2CRs regulate affective behavioral responses to unconditioned aversive stimuli through mechanisms involving the disinhibition of ascending dopaminergic pathways.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Brain
/ Dopamine
/ Dopamine Antagonists - pharmacology
/ Female
/ Heat
/ Male
/ Medicine
/ Mice
/ Pain
/ Phenols (Class of compounds)
/ Receptor, Serotonin, 5-HT2C - physiology
/ Receptors, Dopamine D2 - chemistry
/ Reflex, Startle - drug effects
/ Reflex, Startle - physiology
/ Rodents
/ Stimuli
/ Vocalization, Animal - drug effects
