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Multiparametric Analyses of Human PBMCs Loaded Ex Vivo with a Candidate Idiotype Vaccine for HCV-Related Lymphoproliferative Disorders
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Multiparametric Analyses of Human PBMCs Loaded Ex Vivo with a Candidate Idiotype Vaccine for HCV-Related Lymphoproliferative Disorders
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Multiparametric Analyses of Human PBMCs Loaded Ex Vivo with a Candidate Idiotype Vaccine for HCV-Related Lymphoproliferative Disorders
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Journal Article
Multiparametric Analyses of Human PBMCs Loaded Ex Vivo with a Candidate Idiotype Vaccine for HCV-Related Lymphoproliferative Disorders
2012
Overview
Hepatitis C virus (HCV) has been identified as one of the major risk factors for type II mixed cryoglobulinemia (MC), during the clinical evolution of chronic hepatitis, which may lead to development of B cell non-Hodgkin's lymphoma (NHL). We have previously shown that the candidate idiotype vaccine, based on the IGKV3-20 light chain protein, is able to induce activation and maturation of circulating antigen presenting cells (APCs) in both HCV-positive and HCV-negative healthy control subjects, with production of Th2-type cytokines. Here, the effect of the recombinant IGKV3-20 protein on human peripheral blood mononuclear cells (PBMCs) from HCV-positive subjects, with known blood levels of cryoglobulins, is shown via gene expression profiling analysis combined to multiparameter flow cytometry and multiplex analyses of cytokines.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Antigen-Presenting Cells - immunology
/ Antigens
/ Biology
/ Blood
/ Complications and side effects
/ Female
/ Humans
/ Immunoglobulin Idiotypes - immunology
/ Immunoglobulin Light Chains - immunology
/ Immunoproliferative diseases
/ Kinases
/ Leukocytes, Mononuclear - immunology
/ Leukocytes, Mononuclear - metabolism
/ Leukocytes, Mononuclear - virology
/ Lymphoma
/ Lymphoproliferative disorders
/ Lymphoproliferative Disorders - blood
/ Lymphoproliferative Disorders - genetics
/ Lymphoproliferative Disorders - immunology
/ Male
/ Medicine
/ Patients
/ Peripheral blood mononuclear cells
/ Recombinant Proteins - immunology
/ Transcriptional Activation - immunology
/ Vaccines
/ Viruses
