Journal Article

Opportunities and barriers to implementing antibiotic stewardship in low and middle-income countries: Lessons from a mixed-methods study in a tertiary care hospital in Ethiopia

Fenta, Teferi Gedif, Amogne, Wondwossen, Libman, Michael, Gebretekle, Gebremedhin Beedemariam, Abebe, Workeabeba, Yansouni, Cedric P., Tenna, Admasu, Haile Mariam, Damen, Semret, Makeda

2018

Overview

Global action plans to tackle antimicrobial resistance (AMR) include implementation of antimicrobial stewardship (AMS), but few studies have directly addressed the challenges faced by low and middle-income countries (LMICs). Our aim was to explore healthcare providers' knowledge and perceptions on AMR, and barriers/facilitators to successful implementation of a pharmacist-led AMS intervention in a referral hospital in Ethiopia. Tikur Anbessa Specialized Hospital (TASH) is an 800-bed tertiary center in Addis Ababa, and the site of an ongoing 4-year study on AMR. Between May and July 2017, using a mixed approach of quantitative and qualitative methods, we performed a cross-sectional survey of pharmacists and physicians using a pre-tested questionnaire and semi-structured interviews of purposively selected respondents until thematic saturation. We analyzed differences in proportions of agreement between physicians and pharmacists using χ2 and fisher exact tests. Qualitative data was analyzed thematically. A total of 406 survey respondents (358 physicians, 48 pharmacists), and 35 key informants (21 physicians and 14 pharmacists) were enrolled. The majority of survey respondents (>90%) strongly agreed with statements regarding the global scope of AMR, the need for stewardship, surveillance and education, but their perceptions on factors contributing to AMR and their knowledge of institutional resistance profiles for common bacteria were less uniform. Close to 60% stated that a significant proportion of S. aureus infections were caused by methicillin-resistant strains (an incorrect statement), while only 48% thought a large proportion of gram-negative infections were caused by cephalosporin-resistant strains (a true statement). Differences were noted between physicians and pharmacists: more pharmacists agreed with statements on links between use of broad-spectrum antibiotics and AMR (p<0.022), but physicians were more aware that lack of diagnostic tests led to antibiotic overuse (p<0.01). More than cost, fear of treatment failure and of retribution from senior physicians were major drivers of antibiotic prescription behavior particularly among junior physicians. All respondents identified high turnover of pharmacists, poor communication between the laboratory, pharmacists and clinicians as potential challenges; but the existing hierarchical culture and academic setting were touted as opportunities to implement AMS in Ethiopia. This knowledge and perceptions survey identified specific educational priorities and implementation strategies for AMS in our setting. This is likely also true in other LMICs, where expertise and infrastructure may be lacking.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Antibiotics / Antiinfectives and antibacterials / Antimicrobial agents / Antimicrobial resistance / Antimicrobial Stewardship - economics / Antimicrobial Stewardship - methods / Antimicrobial Stewardship - organization & administration / Antimicrobial Stewardship - standards / Attitude of Health Personnel / Bacteriology / Biology and Life Sciences / Cephalosporins / Communication Barriers / Control / Cross-Sectional Studies / Data processing / Demographic aspects / Developing Countries - statistics & numerical data / Diagnostic systems / Drug resistance / Drug stores / Ethiopia - epidemiology / Expenditures / Female / Guideline Adherence - economics / Guideline Adherence - organization & administration / Guideline Adherence - standards / Guideline Adherence - statistics & numerical data / Health care / Health Knowledge, Attitudes, Practice / Health Plan Implementation - economics / Health Plan Implementation - methods / Health Plan Implementation - organization & administration / Health policy / Health sciences / Health surveillance / Hospitals / Humans / Income / Infections / Infectious diseases / Infrastructure / Internal medicine / Interviews as Topic / Laboratories / Male / Medical personnel / Medicine / Medicine and Health Sciences / Methicillin / Microbial drug resistance / Microbiology / Middle Aged / Mixed methods research / Pediatrics / People and Places / Perception / Pharmacists / Pharmacists - psychology / Pharmacists - statistics & numerical data / Physicians / Physicians - psychology / Physicians - statistics & numerical data / Polls & surveys / Poverty - statistics & numerical data / Public health / Qualitative analysis / Research and Analysis Methods / Strains (organisms) / Tertiary Care Centers - economics / Tertiary Care Centers - statistics & numerical data / Tropical diseases / Young Adult