Asset Details
Do you wish to reserve the book?
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study
Do you wish to request the book?
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study
2014
Overview
PYY is an appetite suppressing hormone. Low circulating PYY has been linked to greater BMI. However data is controversial and this association has not been verified in large human populations.
The purpose of this study was to investigate if fasting serum total PYY is associated with obesity status and/or adiposity at the population level.
A total of 2094 subjects (Male-523, Female-1571) participated in this investigation. Total PYY was measured in fasting serum by enzyme-linked immunosorbent assay. Obesity status (NW-normal-weight, OW-overweight and OB-obese) was determined by the Bray Criteria according to body fat percentage measured by dual-energy x-ray absorptiometry and the WHO criteria according to BMI. One-way ANOVA and multiple regression was used to assess the adiposity-specific association between PYY and the following; weight, BMI, waist-circumference, hip-circumference, waist-hip ratio, percent body fat (%BF), trunk fat (%TF), android fat (%AF) and gynoid fat (%GF).
PYY was not significantly different among NW, OW and OB groups defined by neither %BF nor BMI for both men and women. However among women, fasting PYY was positively associated with adiposity measures. Women with the highest (Top 33%) waist-circumference, %BF and %TF had significantly higher PYY (10.5%, 8.3% and 9.2% respectively) than women with the lowest (Bottom 33%). Age, smoking, medication use and menopause were all positively associated with PYY levels in women but not in men.
To our knowledge this is the largest population based study, with the most comprehensive analysis and measures of confounding factors, to explore the relationship of circulating PYY with obesity. Contrary to initial findings in the literature we discovered that PYY was positively associated with body fat measures (waist-circumference, %BF and %TF) in women. Although the effect size of the positive association of PYY with obesity in women is small, and potentially negligible, it may in fact represent a protective response against significant weight gain.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Aged
/ Analysis
/ Appetite
/ Body fat
/ Criteria
/ Diet
/ Drugs
/ Dual energy X-ray absorptiometry
/ Energy
/ Enzyme-linked immunosorbent assay
/ Fasting
/ Female
/ Hip
/ Hormones
/ Humans
/ Male
/ Medicine
/ Medicine and Health Sciences
/ Nicotine
/ Obesity
/ Peptides
/ Rodents
/ Smoking
/ Studies
