Journal Article

Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials

Ren, Yin, Ruan, Zhongbao, Wu, Yucheng, Zhang, Qingqing

2017

Overview

To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials. Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model. Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin. Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Bile / Biology and Life Sciences / Cholesterol, HDL - blood / Cholesterol, LDL - blood / Consumption / Control methods / Diabetes / Dietary supplements / Ecology and Environmental Sciences / Effectiveness / Food / High density lipoprotein / Inulin / Lactobacillus / Lactobacillus - physiology / Lipid Metabolism - drug effects / Lipids / Lipoproteins test / Low density lipoprotein / Mathematical models / Medical ethics / Medicine and Health Sciences / Meta-analysis / Physical Sciences / Probiotics / Probiotics - pharmacology / Randomized Controlled Trials as Topic / Research and Analysis Methods / Reviews / Rodents / Serum lipids / Studies / Triglycerides - blood