Journal Article

Neurodevelopment of children exposed intra-uterus by Zika virus: A case series

Lopes Moreira, Maria Elisabeth, Brasil, Patricia, Costa, Roozemeria Pereira, Nielsen-Saines, Karin, Peçanha, Pedro Massaroni, Pone, Sheila Moura, Brickley, Elizabeth, Meio, Maria Dalva Barbosa Baker, Vilibor, Renata Hydee Hasue, Gomes Junior, Saint Clair, Vasconcelos, Zilton, Zin, Andrea, Pone, Marcos Vinicius da Silva

2020

Overview

The main goal of this manuscript was to investigate the neurodevelopment of children exposed by Zika virus in the intrauterine period who are asymptomatic at birth. Newborns with documented Zika virus exposure during the intrauterine period who were asymptomatic at birth were followed in the first two years of life for neurodevelopment using Bayley III test. Children were classified as having normal or delayed neurodevelopment for age based on most recent Bayley III evaluation results. Eighty-four infants were included in the study. The first Bayley III evaluation was performed at a mean chronological age of 9.7±3.1 month; 13 children (15%) had a delay in one of the three domains, distributed as follow: 10 (12%) in the language domain and 3 (3.5%) in the motor domain. The most recent Bayley III evaluation was performed at a mean age 15.3±3.1 months; 42 children (50%) had a delay in one of the three domains: 4 (5%) in cognition, 31 (37%) in language, and 20 (24%) in motor performance. There were no statistical differences in Gender, Gestational Age, Birth Weight and Head Circurference at birth between children with normal and delayed neurodevelopment for age. A very high proportion of children exposed ZIKV during pregnancy who were asymptomatic at birth demonstrated a delay in neurodevelopment, mainly in the language domain, the first two years of life.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Age / Biology and Life Sciences / Birth weight / Childbirth & labor / Children / Cognition / Delay / Domains / Exposure / Family income / Female / Gestational Age / Guillain-Barre syndrome / Humans / Infant / Infants / Infections / Language / Male / Medicine and Health Sciences / Microcephaly / Mothers / Motor task performance / Neonates / Neurodevelopment / Neurodevelopmental Disorders - etiology / Neurodevelopmental Disorders - pathology / Newborn babies / Newborn infants / Parturition / People and Places / Pregnancy / Pregnancy Complications, Infectious - etiology / Pregnancy Complications, Infectious - pathology / Prenatal Exposure Delayed Effects - etiology / Prenatal Exposure Delayed Effects - pathology / Public health / Social Sciences / Uterus / Uterus - virology / Vector-borne diseases / Viruses / Young Adult / Zika virus / Zika Virus - isolation & purification / Zika Virus Infection - complications / Zika Virus Infection - virology