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Pneumococcal colonization among tracheostomy tube dependent children
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Pneumococcal colonization among tracheostomy tube dependent children
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Journal Article
Pneumococcal colonization among tracheostomy tube dependent children
2018
Overview
Streptococcus pneumoniae colonization is a precursor to pneumococcal disease. Although children with a tracheostomy have an increased risk of pneumococcal pneumonia, the pneumococci colonizing their lower airways remain largely uncharacterized. We sought to compare lower respiratory tract isolates colonizing tracheostomy patients and a convenience sample of isolates from individuals intubated for acute conditions. We collected pneumococcal isolates from the lower respiratory tract of 27 patients with a tracheostomy and 42 patients intubated for acute conditions. We compared the penicillin susceptibility, rates of co-colonization, genetic background, and serotype of isolates colonizing these patient populations. Isolates from both groups showed high genetic diversity. Forty multi-locus sequence types and 20 serotypes were identified. There was no significant difference in serotype distribution, co-colonization rates, vaccine coverage, or non-susceptibility to penicillin among pneumococcal isolates from the two groups. Colonization of the lower airways with non-vaccine serotypes 15B/C, 23B and 35B was noted for the first time in patients with tracheostomies and supports recently observed increases in nasopharyngeal colonization and disease due to these serotypes.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Child
/ Children
/ Female
/ Humans
/ Infant
/ Male
/ Medicine
/ Medicine and Health Sciences
/ Ostomy
/ Patients
/ Penicillins - therapeutic use
/ Pneumococcal Vaccines - immunology
/ Pneumonia, Pneumococcal - drug therapy
/ Pneumonia, Pneumococcal - microbiology
/ Pneumonia, Pneumococcal - prevention & control
/ Respiratory Insufficiency - therapy
/ Respiratory tract infections
/ Streptococcus pneumoniae - drug effects
/ Streptococcus pneumoniae - isolation & purification
/ Vaccines
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