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Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system
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Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system
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Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system
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Journal Article
Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system
2018
Overview
In this study, we identify the means by which segmentally homologous neurons acquire different neuropeptide fates in Drosophila. Ventral abdominal (Va)-neurons in the A1 segment of the ventral nerve cord express DH31 and AstA neuropeptides (neuropeptidergic fate I) by virtue of Ubx activity, whereas the A2-A4 Va-neurons express the Capa neuropeptide (neuropeptidergic fate II) under the influence of abdA. These different fates are attained through segment-specific programs of neural subtype specification undergone by segmentally homologous neurons. This is an attractive alternative by which Hox genes can shape Drosophila segmental neural architecture (more sophisticated than the previously identified binary \"to live\" or \"not to live\" mechanism). These data refine our knowledge of the mechanisms involved in diversifying neuronal identity within the central nervous system.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ Animals
/ Central Nervous System - metabolism
/ Drosophila melanogaster - embryology
/ Drosophila melanogaster - metabolism
/ Drosophila Proteins - metabolism
/ Female
/ Gene Expression Regulation, Developmental
/ Genes
/ Homeodomain Proteins - genetics
/ Homology
/ Insect Hormones - metabolism
/ Insects
/ Male
/ Medicine and Health Sciences
/ Neurons
/ Nuclear Proteins - metabolism
/ Research and Analysis Methods
