Journal Article

The effects of pulmonary rehabilitation on inflammatory biomarkers in patients with chronic obstructive pulmonary disease: Protocol for a systematic review and meta-analysis

Oliveira, Ana, Newman, Anastasia N. L., Goldstein, Roger, Farley, Christopher, Nair, Parameswaran, Brooks, Dina

2023

Overview

Chronic obstructive pulmonary disease (COPD) is a common, preventable lung disease which affects more than 300 million people worldwide. People with COPD have elevated levels of inflammatory biomarkers, which are linked to physiological alterations in the respiratory system and extrapulmonary manifestations. Pulmonary rehabilitation (PR) is one of the strategies used in the management of individuals with COPD irrespective of severity, however its effect on systemic inflammation is poorly understood. We report the protocol of a systematic review on the effects of PR on systemic inflammation in patients with COPD. Using the search terms \"chronic obstructive pulmonary disease\", \"pulmonary rehabilitation\", and \"inflammatory biomarkers\" and their synonyms, five databases (AMED, CINAHL, Ovid MEDLINE, MEDLINE (Pubmed), EMBASE) will be searched from their inception to identify primary literature evaluating the effects of PR on systemic inflammation. Two reviewers will independently screen titles, abstracts, and full texts for eligibility using the Covidence web-based software. Eligible studies must be published in a peer-reviewed journal and include: (1) participants with COPD undergoing PR with an exercise component of at least 4 weeks in length and (2) a measure of systemic inflammation (e.g., bloodwork or sputum sample) as an outcome of interest. We will use the Cochrane Risk of Bias Tools (ROB2 and ROBINS-I) and will rate the quality of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool. This protocol has followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines and is registered with the International Prospective Register of Systematic Reviews (PROSPERO). The results of this systematic review will summarize the status of the evidence highlighting the effect of PR on systemic inflammation. A manuscript will be drafted and submitted to a peer-reviewed journal and shared at conferences.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Airway management / Analysis / Bias / Biological markers / Biology and Life Sciences / Biomarkers / C-reactive protein / Cardiovascular disease / Care and treatment / Chemokines / Chronic obstructive pulmonary disease / Clinical trials / Cytokines / Diabetes / Diagnosis / Evaluation / Exercise / Exercise therapy / Humans / Inflammation / Intervention / Leukocytes / Literature reviews / Lung diseases / Lung diseases, Obstructive / Medicine and Health Sciences / Meta-analysis / Meta-Analysis as Topic / Metabolic syndrome / Mortality / Neutrophils / Obstructive lung disease / Osteoporosis / Patient outcomes / Patients / Physiological aspects / Proteins / Pulmonary Disease, Chronic Obstructive / Quality / Rehabilitation / Research and Analysis Methods / Respiratory diseases / Respiratory system / Software / Sputum / Study Protocol / Systematic review / Systematic Reviews as Topic