Asset Details
Do you wish to reserve the book?
Increased QPCT gene expression by the hepatitis B virus promotes HBV replication
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Increased QPCT gene expression by the hepatitis B virus promotes HBV replication
Do you wish to request the book?
Increased QPCT gene expression by the hepatitis B virus promotes HBV replication
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Increased QPCT gene expression by the hepatitis B virus promotes HBV replication
2024
Overview
Glutamine cyclase, an enzyme involved in posttranslational modifications, is encoded by the glutaminyl-peptide cyclotransferase (QPCT) gene. Gene microarray analysis revealed that the QPCT gene was highly expressed in HepG2.2.15 cells compared with that in HepG2 cells. The serum expression level of the QPCT gene was detected by ELISA and was significantly greater in HBV-infected patients than in healthy controls. The mRNA and protein expression levels of the QPCT gene were markedly greater in the HBV-expressing cell lines (HepG2.2.15, and HepG2 and Huh7 cells transfected with the pBlu-HBV plasmid) than in the HepG2 and Huh7 cells. The levels of HBV pgRNA and HBV-DNA copy number, as well as the levels of HBeAg and HBsAg, also increased in the HepG2 and Huh7 cell lines cotransfected with the QPCT gene expression plasmid and the HBV 1.3-fold plasmid. Our study indicated that HBV can promote the expression of the QPCT gene, which in turn promotes the expression and replication of HBV.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ Antigens
/ Enzyme-linked immunosorbent assay
/ Enzymes
/ Female
/ Genes
/ Genomes
/ Glutaminyl-peptide cyclotransferase
/ Hepatitis B e Antigens - genetics
/ Hepatitis B e Antigens - metabolism
/ Hepatitis B Surface Antigens - genetics
/ Hepatitis B Surface Antigens - metabolism
/ Hepatitis B virus - genetics
/ Hepatitis B virus - physiology
/ Humans
/ Male
/ Medicine and Health Sciences
/ Plasmids
/ Proteins
/ Research and Analysis Methods
/ Virus Replication - genetics
/ Viruses
