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SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022
by
Dominguez, Samuel R.
, Bankers, Laura
, Armistead, Isaac
, Burakoff, Alexis
, Ho, Erin
, O’Brien, Shannon C.
, Matzinger, Shannon R.
, Tapay, Diana M.
in
Adolescent
/ Care and treatment
/ Child
/ Child, Preschool
/ Colorado
/ Colorado - epidemiology
/ Communicable diseases in children
/ Comparative analysis
/ coronavirus disease
/ COVID-19
/ COVID-19 - epidemiology
/ COVID-19 - virology
/ COVID-19 vaccines
/ Development and progression
/ Disease
/ Diseases
/ Emergency medical care
/ Evaluation
/ Female
/ Health surveillance
/ Hospital patients
/ Hospitalization
/ Hospitals
/ Host-virus relationships
/ Humans
/ Immunization
/ Infant
/ Infant, Newborn
/ Infections
/ Male
/ Methods
/ Outpatient care facilities
/ Patients
/ Pediatrics
/ Prognosis
/ Public health
/ respiratory infections
/ Review boards
/ SARS-CoV-2
/ Sentinel health events
/ Severe acute respiratory syndrome coronavirus 2
/ Severity of Illness Index
/ United Kingdom
/ Viral Load
/ viruses
/ Whole genome sequencing
/ Young Adult
2024
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SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022
by
Dominguez, Samuel R.
, Bankers, Laura
, Armistead, Isaac
, Burakoff, Alexis
, Ho, Erin
, O’Brien, Shannon C.
, Matzinger, Shannon R.
, Tapay, Diana M.
in
Adolescent
/ Care and treatment
/ Child
/ Child, Preschool
/ Colorado
/ Colorado - epidemiology
/ Communicable diseases in children
/ Comparative analysis
/ coronavirus disease
/ COVID-19
/ COVID-19 - epidemiology
/ COVID-19 - virology
/ COVID-19 vaccines
/ Development and progression
/ Disease
/ Diseases
/ Emergency medical care
/ Evaluation
/ Female
/ Health surveillance
/ Hospital patients
/ Hospitalization
/ Hospitals
/ Host-virus relationships
/ Humans
/ Immunization
/ Infant
/ Infant, Newborn
/ Infections
/ Male
/ Methods
/ Outpatient care facilities
/ Patients
/ Pediatrics
/ Prognosis
/ Public health
/ respiratory infections
/ Review boards
/ SARS-CoV-2
/ Sentinel health events
/ Severe acute respiratory syndrome coronavirus 2
/ Severity of Illness Index
/ United Kingdom
/ Viral Load
/ viruses
/ Whole genome sequencing
/ Young Adult
2024
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SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022
by
Dominguez, Samuel R.
, Bankers, Laura
, Armistead, Isaac
, Burakoff, Alexis
, Ho, Erin
, O’Brien, Shannon C.
, Matzinger, Shannon R.
, Tapay, Diana M.
in
Adolescent
/ Care and treatment
/ Child
/ Child, Preschool
/ Colorado
/ Colorado - epidemiology
/ Communicable diseases in children
/ Comparative analysis
/ coronavirus disease
/ COVID-19
/ COVID-19 - epidemiology
/ COVID-19 - virology
/ COVID-19 vaccines
/ Development and progression
/ Disease
/ Diseases
/ Emergency medical care
/ Evaluation
/ Female
/ Health surveillance
/ Hospital patients
/ Hospitalization
/ Hospitals
/ Host-virus relationships
/ Humans
/ Immunization
/ Infant
/ Infant, Newborn
/ Infections
/ Male
/ Methods
/ Outpatient care facilities
/ Patients
/ Pediatrics
/ Prognosis
/ Public health
/ respiratory infections
/ Review boards
/ SARS-CoV-2
/ Sentinel health events
/ Severe acute respiratory syndrome coronavirus 2
/ Severity of Illness Index
/ United Kingdom
/ Viral Load
/ viruses
/ Whole genome sequencing
/ Young Adult
2024
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SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022
Journal Article
SARS-CoV-2 Disease Severity and Cycle Threshold Values in Children Infected during Pre-Delta, Delta, and Omicron Periods, Colorado, USA, 2021–2022
2024
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Overview
In adults, viral load and disease severity can differ by SARS-CoV-2 variant, patterns less understood in children. We evaluated symptomatology, cycle threshold (Ct) values, and SARS-CoV-2 variants among 2,299 pediatric SARS-CoV-2 patients (0-21 years of age) in Colorado, USA, to determine whether children infected with Delta or Omicron had different symptom severity or Ct values than during earlier variants. Children infected during the Delta and Omicron periods had lower Ct values than those infected during pre-Delta, and children <1 year of age had lower Ct values than older children. Hospitalized symptomatic children had lower Ct values than asymptomatic patients. Compared with pre-Delta, more children infected during Delta and Omicron were symptomatic (75.4% pre-Delta, 95.3% Delta, 99.5% Omicron), admitted to intensive care (18.8% pre-Delta, 39.5% Delta, 22.9% Omicron), or received oxygen support (42.0% pre-Delta, 66.3% Delta, 62.3% Omicron). Our data reinforce the need to include children, especially younger children, in pathogen surveillance efforts.
Publisher
U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention
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