Asset Details
Do you wish to reserve the book?
Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum
Do you wish to request the book?
Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum
2020
Overview
House dust contains many organic contaminants that can compete with the thyroid hormone (TH) thyroxine (
) for binding to transthyretin (TTR). How these contaminants work together at levels found in humans and how displacement from TTR
relates to
-TTR binding is unknown.
Our aims were to determine the TTR-binding potency for contaminant mixtures as found in house dust, maternal serum, and infant serum; to study whether the TTR-binding potency of the mixtures follows the principle of concentration addition; and to extrapolate the
TTR-binding potency to
inhibition levels of
-TTR binding in maternal and infant serum.
Twenty-five contaminants were tested for their
capacity to compete for TTR-binding with a fluorescent FITC-
probe. Three mixtures were reconstituted proportionally to median concentrations for these chemicals in house dust, maternal serum, or infant serum from Nordic countries. Measured concentration-response curves were compared with concentration-response curves predicted by concentration addition. For each reconstituted serum mixture, its inhibitor-TTR dissociation constant (
) was used to estimate inhibition levels of
-TTR binding in human blood.
The TTR-binding potency of the mixtures was well predicted by concentration addition. The
inhibition in FITC-
binding observed for the mixtures reflecting median concentrations in maternal and infant serum was extrapolated to 1.3% inhibition of
-TTR binding in maternal and 1.5% in infant blood. For nontested mixtures reflecting high-end serum concentrations, these estimates were 6.2% and 4.9%, respectively.
The relatively low estimated inhibition levels at median exposure levels may explain why no relationship between exposure to TTR-binding compounds and circulating
levels in humans has been reported, so far. We hypothesize, however, that 1.3% inhibition of
-TTR binding may ultimately be decisive for reaching a status of maternal hypothyroidism or hypothyroxinemia associated with impaired neurodevelopment in children. https://doi.org/10.1289/EHP5911.
Publisher
National Institute of Environmental Health Sciences,Environmental Health Perspectives
Subject
/ Babies
/ Binding
/ Blood
/ Dust
/ Endocrine Disruptors - analysis
/ Endocrine Disruptors - toxicity
/ Humans
/ In house
/ Infants
/ PCB
/ Perfluoroalkyl & polyfluoroalkyl substances
/ Phenols
/ Plasma
/ Polybrominated diphenyl ethers
/ Proteins
/ Studies
/ Thyroid
/ Thyroid Gland - drug effects
/ VOCs
