Journal Article

Metabolic engineering of microbial cell factories for production of nutraceuticals

Yuan, Shuo-Fu, Alper, Hal S.

2019

Overview

Metabolic engineering allows for the rewiring of basic metabolism to overproduce both native and non-native metabolites. Among these biomolecules, nutraceuticals have received considerable interest due to their health-promoting or disease-preventing properties. Likewise, microbial engineering efforts to produce these value-added nutraceuticals overcome traditional limitations of low yield from extractions and complex chemical syntheses. This review covers current strategies of metabolic engineering employed for the production of a few key nutraceuticals with selecting polyunsaturated fatty acids, polyphenolic compounds, carotenoids and non-proteinogenic amino acids as exemplary molecules. We focus on the use of both mono-culture and co-culture strategies to produce these molecules of interest. In each of these cases, metabolic engineering efforts are enabling rapid production of these molecules.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Amino acids / Analysis / Applied Microbiology / Biochemistry / Biomolecules / Biotechnology / Carotenoids / Cell culture / Chemical synthesis / Chemistry / Chemistry and Materials Science / Co-culture system / Consortia / Constructing 'intelligent' microbial cell factories / E coli / Engineering / Enzymology / Ethanol / Fatty acids / Fermentation / Food / Functional foods / Functional foods & nutraceuticals / Genetic Engineering / Glucose / Health / Health promotion / Industrial engineering / International agreements / Lipids / Manufacturing engineering / Metabolic engineering / Metabolism / Metabolites / Microbial Genetics and Genomics / Microbiology / Microorganisms / Nutraceuticals / Organic chemistry / Organisms / Polyphenols / Polyunsaturated fatty acids / Review / Rewiring / Unsaturated fatty acids / Value-added products