Journal Article

Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review

Zhang, Hong, Zhang, Zhenhai, Sun, Qiang, Liu, Xiaorong

2016

Overview

Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy. PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups. A total of 22 studies (n = 1657) met inclusion criteria. The mean Newcastle-Ottawa Scale (NOS) score was 7.2 and ranged from 6 to 8. The standard mean difference(SMD) in the meta-analysis of 20 studies of the level of Gd-IgA1 in the serum and/or supernatant of cultured cells was higher in the IgAN group compared with healthy controls as well as in those with other renal diseases (SMD = 1.76, 95% CI = 1.18-2.34, P<0.00001; SMD = 1.05, 95% CI = 0.05-2.04, P = 0.04). The data synthesis suggested that IgAN patients had similar levels of serum Gd-IgA1, with no significant differences, compared with first-degree relatives and Henoch-Schonlein purpura nephritis (HSPN) patients (MD = 0.04, 95% CI = 0.00-0.08, P = 0.05; MD = -46.03, 95% CI = -217.70-125.64, P = 0.60). In addition, the combined MD of 5 studies indicated that there were no significant differences in Gd-IgA1 levels among patients with varying severities of IgAN (MD = 0.02, 95% CI = -0.02-0.05, P = 0.28). The pooled evidence suggests that the level of Gd-IgA1 in the serum or supernatant of cultured cells from peripheral blood or tonsils may be a useful biomarker for predicting IgA nephropathy, though the level of Gd-IgA1 was not significantly associated with disease severity.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Biology and Life Sciences / Biomarkers / Biomarkers - blood / Biomarkers - chemistry / Biopsy / Clinical trials / Comparative analysis / DNA methylation / Early Diagnosis / Female / Gadolinium / Galactose / Galactose - metabolism / Gene expression / Glomerulonephritis, IGA - immunology / Glycosylation / Hospitals / Humans / IgA nephropathy / Immunoglobulin A / Immunoglobulin A - blood / Immunoglobulin A - chemistry / Immunoglobulins / Immunology / Kidney diseases / Kidney transplantation / Laboratories / Male / Mass spectrometry / Medical research / Medicine and Health Sciences / Meta-analysis / Nephritis / Nephrology / Nitric-oxide synthase / Patients / Pediatrics / Peripheral blood / Physical Sciences / Predictive control / Randomized Controlled Trials as Topic / Research and Analysis Methods / Schonlein-Henoch purpura / Scientific imaging / Studies / Systematic review / Systemic diseases / Vasoactive intestinal peptide