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Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin
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Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin
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Journal Article
Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin
2018
Overview
1-Deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor and thus beneficial for prevention of diabetes. While we have succeeded in obtaining the culture supernatant extract (CSE) rich in DNJ from microorganism source, information regarding its anti-hyperglycemic effect and safety were still limited. Therefore, this study was aimed to evaluate the anti-hyperglycemic effect and safety of microorganism DNJ. Oral sucrose tolerance test was performed, and the result showed that CSE was able to significantly suppress the blood glucose elevation and suggested DNJ as the main active compound. To determine its safety, the absorption and excretion of microorganism DNJ were evaluated using 15N labeling method. Our findings investigated the recovery rate of 15N from DNJ reached 80% up to 48 hours after oral administration, suggesting its rapid excretion, suggesting the safety of DNJ. This study verified the functional properties and safety of DNJ from microorganisms, suggesting its potential use for functional purpose.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
1-Deoxynojirimycin - administration & dosage
/ 1-Deoxynojirimycin - analysis
/ 1-Deoxynojirimycin - metabolism
/ Animals
/ Bacillus amyloliquefaciens - chemistry
/ Bacillus amyloliquefaciens - metabolism
/ Chromatography, High Pressure Liquid
/ Diabetes
/ Drug Evaluation, Preclinical
/ Food
/ Hypoglycemic Agents - administration & dosage
/ Hypoglycemic Agents - analysis
/ Hypoglycemic Agents - metabolism
/ Male
/ Medicine and Health Sciences
/ Mice
/ Mulberry
/ Nitrogen Isotopes - chemistry
/ Nitrogen Isotopes - metabolism
/ Rodents
/ Safety
/ Sucrose
/ Sugar
