Asset Details
Do you wish to reserve the book?
The evolution of gene expression levels in mammalian organs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The evolution of gene expression levels in mammalian organs
Do you wish to request the book?
The evolution of gene expression levels in mammalian organs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The evolution of gene expression levels in mammalian organs
2011
Overview
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals.
Gene expression and species difference
Genome analyses can uncover protein-coding changes that potentially underlie the differences between species, but many of the phenotypic differences between species are the result of regulatory mutations affecting gene expression. Brawand
et al
. use high-throughput RNA sequencing to study the evolutionary dynamics of mammalian transcriptomes in six major tissues (cortex, cerebellum, heart, kidney, liver and testis) from ten species from all major mammalian lineages. Among the findings is the extent of transcriptome variation between organs and species, as well as the identification of potentially selectively driven expression switches that may have shaped specific organ biology.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biochemistry, Molecular Biology
/ Biological and medical sciences
/ Brain
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Genetics
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Mammals
/ Molecular and cellular biology
/ Principal Component Analysis
/ Science
/ Transcription. Transcription factor. Splicing. Rna processing
/ Trees
