Journal Article

Avenanthramide supplementation attenuates exercise-induced inflammation in postmenopausal women

Koenig, Ryan, Ji, Li Li, Zhang, Tianou, Dickman, Jonathan R, Kang, Chounghun, Chu, Yi-Fang

2014

Overview

During aging, chronic systemic inflammation increases in prevalence and antioxidant balance shifts in favor of oxidant generation. Avenanthramide (AVA) is a group of oat phenolics that have shown anti-inflammatory and antioxidant capability. The present study investigated whether dietary supplementation of avenanthramides (AVA) in oats would increase antioxidant protection and reduce inflammation after a bout of downhill walking (DW) in postmenopausal women. Women at age of 50–80 years (N = 16) were randomly divided into two groups in a double-blinded fashion, receiving two cookies made of oat flour providing 9.2 mg AVA or 0.4 mg AVA (control, C) each day for 8 weeks. Before and after the dietary regimen, each group of subjects walked downhill on a treadmill (−9% grade) for 4 bouts of 15 minutes at a speed of 4.0 km/h with 5 minutes rest between sessions. Blood samples were collected at rest, 24 h post-DW, and 48 h post-DW pre- and post-supplementation. Both DW sessions increased plasma creatine kinase activity (P < 0.05). Before supplementation, in vitro neutrophil respiratory burst (NRB) activity was increased at 24 h post-DW (P < 0.05) and C-reactive protein (CRP) was increased 48 h post-DW (P < 0.05). AVA supplementation decreased DW-induced NRB at 24 h (P < 0.05) and CRP level 48 h (P < 0.05). Plasma interleukin (IL)-1β concentration and mononuclear cell nuclear factor (NF) κB binding were suppressed at rest and during post-DW period in AVA but not C group (P < 0.05). Plasma total antioxidant capacity (P < 0.05) and erythrocyte superoxide dismutase activity were increased in AVA vs. C (P < 0.05), whereas glutathione redox status was elevated 48 h post-DW but not affected by AVA. Thus, chronic AVA supplementation decreased systemic and DW-induced inflammation and increased blood-borne antioxidant defense in postmenopausal women.

• Publisher: Springer-Verlag,BioMed Central,BioMed Central Ltd,Springer Nature B.V
• Subject: Acids / Aged / Aged, 80 and over / Aging / Aging - physiology / Anti-Inflammatory Agents - therapeutic use / antioxidant activity / Antioxidants / Antioxidants - metabolism / Avena - chemistry / avenanthramides / Blood / C-reactive protein / C-Reactive Protein - metabolism / Clinical Nutrition / cookies / Creatine kinase / Creatine Kinase - blood / Cytokines / Dietary Supplements / Double-Blind Method / Drug dosages / erythrocytes / exercise / Exercise Test / Female / Free radicals / Gene expression / glutathione / Health aspects / Health Promotion and Disease Prevention / Human subjects / Humans / inflammation / Inflammation - blood / Inflammation - drug therapy / Interleukin-1beta - blood / Interleukin-6 - blood / interleukins / Kinases / Medicine / Medicine & Public Health / Middle Aged / Muscular system / Musculoskeletal system / neutrophils / NF-kappa B - blood / oat flour / Oats / ortho-Aminobenzoates - therapeutic use / oxidants / Oxidative stress / Oxidizing agents / Phenols / Phytochemicals / Plasma / Postmenopause / Respiratory Burst / Rodents / Studies / superoxide dismutase / Superoxide Dismutase - blood / Walking / women / Womens health