Journal Article

High-intensity, whole-body exercise improves blood pressure control in individuals with spinal cord injury: A prospective randomized controlled trial

Hamner, Jason W., Goldstein, Rich, Taylor, J. Andrew, Solinsky, Ryan, Draghici, Adina

2021

Overview

Blood pressure regulation following spinal cord injury (SCI) is often compromised due to impaired vascular sympathetic control, leading to increased reliance on cardiovagal baroreflex sensitivity to maintain pressure. Whole-body exercise improves cardiovagal baroreflex sensitivity in uninjured individuals, though has not been explored in those with SCI. Our objective was to determine changes in cardiovagal baroreflex sensitivity following 6 months of high-intensity, whole-body exercise in individuals with SCI compared to lower-intensity, arms only exercise, or waitlist. This randomized controlled trial recruited individuals with SCI aged 18–40 years old. Sixty-one individuals were randomized, with 38 completing at least one cardiovagal baroreflex sensitivity assessment. Whole-body exercise was performed with hybrid functional electrical stimulation rowing prescribed as two to three times per week, for 30–60 minutes with a target heart rate of >75% of maximum. The arms only exercise group performed upper body rowing exercise with the same prescription as whole-body exercise. Waitlist controls were not enrolled in any explicit training regimen. After 6 months, those in arms only exercise or waitlist crossed over to whole-body exercise. Cardiovagal baroreflex sensitivity was assessed via the neck suction technique at baseline and at three-month intervals thereafter. Intention to treat analysis with a structured equation model demonstrated no significant effect of waitlist control or arms only exercise on cardiovagal baroreflex sensitivity. Whole-body exercise significantly improved cardiovagal baroreflex sensitivity at 6 months for those initially randomized (p = 0.03), as well as those who crossed over from arms only exercise or waitlist control (p = 0.03 for each). However, amount of exercise performed and aerobic gains (VO 2max ) each poorly correlated with increases in cardiovagal baroreflex sensitivity (R 2 <0.15). In post-hoc analyses, individuals with paraplegia made significantly greater gains in baroreflex sensitivity compared to those with tetraplegia (p = 0.02), though gains within this group were again poorly correlated to gains in aerobic capacity. Clinicaltrials.gov number NCT02139436.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / Baroreceptors / Baroreflex - physiology / Biology and Life Sciences / Blood pressure / Blood Pressure - physiology / Care and treatment / Clinical trials / Editing / Electrical stimuli / Enrollments / Exercise / Exercise - physiology / Exercise Therapy - methods / Female / Fitness training programs / Heart rate / Heart Rate - physiology / Hospitals / Humans / Hypotension / Male / Management / Maximum oxygen consumption / Medical research / Medicine / Medicine and Health Sciences / Methodology / Muscles / Outcome Assessment, Health Care / Oxygen Consumption - physiology / Physical fitness / Physiological aspects / Prospective Studies / Reflexes / Rehabilitation / Reviews / Rowing / Sensitivity / Spinal cord injuries / Spinal Cord Injuries - physiopathology / Spinal Cord Injuries - therapy / Time Factors / Vasoactive agents / Visualization / Young Adult