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Ligand-induced monoubiquitination of BIK1 regulates plant immunity
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Ligand-induced monoubiquitination of BIK1 regulates plant immunity
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Journal Article
Ligand-induced monoubiquitination of BIK1 regulates plant immunity
2020
Overview
Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens
1
–
3
. Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants
4
. The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK
BOTRYTIS
-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)–BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The
Arabidopsis
E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2–BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR–RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.
The detection of microorganism-associated ligands by plant cells activates a signalling cascade in which the kinase BIK1 is monoubiquinated, released from the FLS2–BAK1 complex, and internalized by endocytosis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
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/ Analysis
/ Arabidopsis Proteins - chemistry
/ Arabidopsis Proteins - metabolism
/ Botrytis
/ Humanities and Social Sciences
/ Kinases
/ Ligands
/ Mutation
/ Pathogen-Associated Molecular Pattern Molecules - immunology
/ Pattern recognition receptors
/ Plasma
/ Protein Kinases - metabolism
/ Protein-Serine-Threonine Kinases - chemistry
/ Protein-Serine-Threonine Kinases - metabolism
/ Receptors, Pattern Recognition - immunology
/ Science
/ Ubiquitin-Protein Ligases - chemistry
