Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

by Montine, Thomas J , Ritchie, Karen , Wang, Li-San , Combarros, Onofre , Schellenberg, Gerard D , Beekly, Duane , Gu, Wei , Buxbaum, Joseph D , Holmans, Peter A , Evans, Denis , Fox, Nick C , Morgan, Kevin , Bettens, Karolien , Ibrahim-Verbaas, Carla A , Gudnason, Vilmundur , Pichler, Sabrina , Rotter, Jerome I , Sims, Rebecca , Harris, Tamara B , Pilotto, Alberto , Tzourio, Christophe , Collinge, John , Moskvina, Valentina , Amin, Najaf , Galimberti, Daniela , O'Donovan, Michael C , Russo, Giancarlo , Letenneur, Luc , Wallon, David , Hamilton-Nelson, Kara L , Eiriksdottir, Gudny , Faber, Kelley M , Barberger-Gateau, Pascale , Bihoreau, Marie-Thérèse , Razquin, Cristina , Bis, Joshua C , Del Zompo, Maria , Mead, Simon , Coto, Eliecer , de Bruijn, Renee F A G , Ramirez, Alfredo , Larson, Eric B , Lathrop, Mark , Kunkle, Brian , Zou, Fanggeng , Green, Robert , Kukull, Walter A , Schmidt, Helena , Bayer, Anthony , Rogaeva, Ekaterina , Zelenika, Diana , Lopez, Oscar L , Maier, Wolfgang , Lin, Chiao-Feng , Hakonarson, Hakon , Clarimon, Jordi , Moebus, Susanne , Boerwinkle, Eric , Foroud, Tatiana M , Bennett, David A , Nöthen, Markus M , St George-Hyslop, Peter , Beecham, Ga

in 45 / 45/43 / 631/208/205/2138 / Age of Onset / Aged / Aged, 80 and over / Aging / Agriculture / Alzheimer Disease - epidemiology / Alzheimer Disease - genetics / Alzheimer's disease / Animal Genetics and Genomics / Biomedicine / Cancer Research / Case-Control Studies / Cohort Studies / Female / Gene Function / Genealogy / Genes / Genetic aspects / Genetic Loci / Genetic Predisposition to Disease / Genetic susceptibility / Genetics / Genome-Wide Association Study - statistics & numerical data / Genomes / Genomics / Health risk assessment / Human Genetics / Humans / Identification and classification / letter / Life Sciences / Male / Meta-analysis / Middle Aged / Polymorphism, Single Nucleotide / Quality control / Quantitative trait loci

2013

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Confirm

Do you wish to request the book?

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Montine, Thomas J,

Ritchie, Karen,

Wang, Li-San,

Combarros, Onofre,

Schellenberg, Gerard D,

Beekly, Duane,

Gu, Wei,

Buxbaum, Joseph D,

Holmans, Peter A,

Evans, Denis,

Fox, Nick C,

Morgan, Kevin,

Bettens, Karolien,

Ibrahim-Verbaas, Carla A,

Gudnason, Vilmundur,

Pichler, Sabrina,

Rotter, Jerome I,

Sims, Rebecca,

Harris, Tamara B,

Pilotto, Alberto,

Tzourio, Christophe,

Collinge, John,

Moskvina, Valentina,

Amin, Najaf,

Galimberti, Daniela,

O'Donovan, Michael C,

Russo, Giancarlo,

Letenneur, Luc,

Wallon, David,

Hamilton-Nelson, Kara L,

Eiriksdottir, Gudny,

Faber, Kelley M,

Barberger-Gateau, Pascale,

Bihoreau, Marie-Thérèse,

Razquin, Cristina,

Bis, Joshua C,

Del Zompo, Maria,

Mead, Simon,

Coto, Eliecer,

de Bruijn, Renee F A G,

Ramirez, Alfredo,

Larson, Eric B,

Lathrop, Mark,

Kunkle, Brian,

Zou, Fanggeng,

Green, Robert,

Kukull, Walter A,

Schmidt, Helena,

Bayer, Anthony,

Rogaeva, Ekaterina,

Zelenika, Diana,

Lopez, Oscar L,

Maier, Wolfgang,

Lin, Chiao-Feng,

Hakonarson, Hakon,

Clarimon, Jordi,

Moebus, Susanne,

Boerwinkle, Eric,

Foroud, Tatiana M,

Bennett, David A,

Nöthen, Markus M,

St George-Hyslop, Peter,

Beecham, Ga

2013

Overview

Philippe Amouyel, Julie Williams, Gerard Schellenberg, Sudha Seshadri and colleagues report a meta-analysis of genome-wide association studies for late-onset Alzheimer's disease in 17,008 cases and 37,154 controls with replication in an additional 8,572 cases and 11,312 controls. They identify 11 loci newly associated with Alzheimer's disease. Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance ( P < 5 × 10 −8 ) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 45/43

/ Aged

/ Aging