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Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog
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Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog
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Journal Article
Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog
2003
Overview
During early development in vertebrates, Sonic hedgehog (Shh) is produced by the notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning of the neural tube. However, Shh is also required for the survival of neuroepithelial cells. We show that Patched (Ptc) induces apoptotic cell death unless its ligand Shh is present to block the signal. Moreover, the blockade of Ptc-induced cell death partly rescues the chick spinal cord defect provoked by Shh deprivation. Thus, the proapoptotic activity of unbound Ptc and the positive effect of Shh-bound Ptc on cell differentiation probably cooperate to achieve the appropriate spinal cord development.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
Subject
/ Amygdala
/ Animals
/ Biological and medical sciences
/ Cancer
/ Central Nervous System - cytology
/ Central Nervous System - embryology
/ Central Nervous System - metabolism
/ Embryology and Organogenesis
/ Embryos
/ Epithelial Cells - metabolism
/ Fear
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Intracellular Signaling Peptides and Proteins
/ Ligands
/ Membrane Proteins - chemistry
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Mice
/ Molecular and cellular biology
/ Mutation
/ Neurons
/ Rats
