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Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus , Denmark, 2020–2023
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Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus , Denmark, 2020–2023
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Journal Article
Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus , Denmark, 2020–2023
2024
Overview
Azole-resistant Aspergillus fumigatus (ARAf) fungi have been found inconsistently in the environment in Denmark since 2010. During 2018-2020, nationwide surveillance of clinical A. fumigatus fungi reported environmental TR
/L98H or TR
/Y121F/T289A resistance mutations in 3.6% of isolates, prompting environmental sampling for ARAf and azole fungicides and investigation for selection of ARAf in field and microcosmos experiments. ARAf was ubiquitous (20% of 366 samples; 16% TR
/L98H- and 4% TR
/Y121F/T289A-related mechanisms), constituting 4.2% of 4,538 A. fumigatus isolates. The highest proportions were in flower- and compost-related samples but were not correlated with azole-fungicide application concentrations. Genotyping showed clustering of tandem repeat-related ARAf and overlaps with clinical isolates in Denmark. A. fumigatus fungi grew poorly in the field experiment with no postapplication change in ARAf proportions. However, in microcosmos experiments, a sustained complete (tebuconazole) or partial (prothioconazole) inhibition against wild-type A. fumigatus but not ARAf indicated that, under some conditions, azole fungicides may favor growth of ARAf in soil.
Publisher
U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention
Subject
/ Antifungal Agents - pharmacology
/ Aspergillosis - drug therapy
/ Aspergillosis - epidemiology
/ Aspergillosis - microbiology
/ Aspergillus fumigatus - drug effects
/ Aspergillus fumigatus - genetics
/ Aspergillus fumigatus - isolation & purification
/ Control
/ Drug resistance in microorganisms
/ Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant
/ Fungi
/ Fungicides, Industrial - pharmacology
/ Genotype
/ Humans
/ Identification and classification
/ Manures
/ Mutation
