Journal Article

Professional Exposure to Goats Increases the Risk of Pneumonic-Type Lung Adenocarcinoma: Results of the IFCT-0504-Epidemio Study

Cadranel, Jacques, Lutringer-Magnin, Delphine, Quoix, Elisabeth, Girard, Nicolas, Cottin, Vincent, Signore, Corinne Del, Lebitasy, Marie-Paule, Mornex, Jean-François, Cordier, Geneviève, Leroux, Caroline, Vanhems, Philippe

2012

Overview

Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR) = 3.23, 95% confidence interval (CI): 1.32-7.87, p = 0.010), never-smoker status (OR = 3.57, 95% CI: 1.27-10.00, p = 0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (OR = 3.43, 95% CI: 1.10-10.72, p = 0.034), and professional exposure to goats (OR = 5.09, 95% CI: 1.05-24.69, p = 0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adenocarcinoma / Adenocarcinoma - etiology / Adenocarcinoma - pathology / Adenocarcinoma of Lung / Adolescent / Adult / Animals / Biology / Cancer / Case-Control Studies / Child / Child, Preschool / Confidence intervals / Environmental Exposure / Environmental Exposure - adverse effects / Environmental risk / Epidemiology / Exposure / Female / Goats / Goats - physiology / Health risk assessment / Humans / Infant / Life Sciences / Livestock / Livestock - physiology / Lung / Lung - pathology / Lung cancer / Lung diseases / Lung Neoplasms / Lung Neoplasms - etiology / Lung Neoplasms - pathology / Male / Medicine / Middle Aged / Multivariate analysis / Non-small cell lung cancer / Non-small cell lung carcinoma / Ovis aries / Patients / Proteins / Respiratory system agents / Risk analysis / Risk Factors / Sheep / Smoking / Thorax / Tobacco / Tumors / Veterinary Science / Viruses / Young Adult