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Dopamine-based mechanism for transient forgetting
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Journal Article
Dopamine-based mechanism for transient forgetting
2021
Overview
Active forgetting is an essential component of the memory management system of the brain
1
. Forgetting can be permanent, in which prior memory is lost completely, or transient, in which memory exists in a temporary state of impaired retrieval. Temporary blocks on memory seem to be universal, and can disrupt an individual’s plans, social interactions and ability to make rapid, flexible and appropriate choices. However, the neurobiological mechanisms that cause transient forgetting are unknown. Here we identify a single dopamine neuron in
Drosophila
that mediates the memory suppression that results in transient forgetting. Artificially activating this neuron did not abolish the expression of long-term memory. Instead, it briefly suppressed memory retrieval, with the memory becoming accessible again over time. The dopamine neuron modulates memory retrieval by stimulating a unique dopamine receptor that is expressed in a restricted physical compartment of the axons of mushroom body neurons. This mechanism for transient forgetting is triggered by the presentation of interfering stimuli immediately before retrieval.
A dopamine neuron that underpins transient forgetting in
Drosophila
is activated by the presentation of interfering stimuli immediately before memory retrieval, modulating this retrieval by stimulating a dopamine receptor in mushroom body neurons.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/35
/ 14/63
/ 38/70
/ 38/89
/ 64/24
/ Animals
/ Axons
/ Central Nervous System - cytology
/ Central Nervous System - physiology
/ Dopamine
/ Dopaminergic Neurons - physiology
/ Drosophila melanogaster - cytology
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - metabolism
/ Female
/ Humanities and Social Sciences
/ Memory, Long-Term - physiology
/ Mushroom Bodies - physiology
/ Neurons
/ Odorants
/ Receptors, Dopamine D1 - metabolism
/ Science
