Journal Article

Common genetic variants contribute to risk of rare severe neurodevelopmental disorders

Kelemen, Martin, Radford, Elizabeth J., Barrett, Jeffrey C., Hurles, Matthew E., Wright, Caroline F., Gecz, Jozef, Firth, Helen V., Rice, Daniel L., Gordon, Scott, Fitzpatrick, David R., Niemi, Mari E. K., McAloney, Kerrie, McRae, Jeremy, Yu, Sui, Martin, Nicholas G., Gallone, Giuseppe, Martin, Hilary C.

2018

Overview

There are thousands of rare human disorders that are caused by single deleterious, protein-coding genetic variants 1 . However, patients with the same genetic defect can have different clinical presentations 2 – 4 , and some individuals who carry known disease-causing variants can appear unaffected 5 . Here, to understand what explains these differences, we study a cohort of 6,987 children assessed by clinical geneticists to have severe neurodevelopmental disorders such as global developmental delay and autism, often in combination with abnormalities of other organ systems. Although the genetic causes of these neurodevelopmental disorders are expected to be almost entirely monogenic, we show that 7.7% of variance in risk is attributable to inherited common genetic variation. We replicated this genome-wide common variant burden by showing, in an independent sample of 728 trios (comprising a child plus both parents) from the same cohort, that this burden is over-transmitted from parents to children with neurodevelopmental disorders. Our common-variant signal is significantly positively correlated with genetic predisposition to lower educational attainment, decreased intelligence and risk of schizophrenia. We found that common-variant risk was not significantly different between individuals with and without a known protein-coding diagnostic variant, which suggests that common-variant risk affects patients both with and without a monogenic diagnosis. In addition, previously published common-variant scores for autism, height, birth weight and intracranial volume were all correlated with these traits within our cohort, which suggests that phenotypic expression in individuals with monogenic disorders is affected by the same variants as in the general population. Our results demonstrate that common genetic variation affects both overall risk and clinical presentation in neurodevelopmental disorders that are typically considered to be monogenic. A genome-wide association study of approximately 7,000 patients with neurodevelopmental disorders demonstrates that overall risk and clinical presentation in putative monogenic disorders is also influenced by common genetic variants present in the general population.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 45/43 / 45/61 / 631/208/205/2138 / 631/208/366 / 631/208/727/2000 / 692/699/375/366 / Abnormalities / Analysis / Autism / Autistic Disorder - genetics / Bioinformatics / Birth weight / Birth Weight - genetics / Body Height - genetics / Case-Control Studies / Child health / Children / Cohort Studies / Consortia / Developmental Disabilities - genetics / Diagnostic systems / Disease / Disorders / Educational attainment / Female / Genetic aspects / Genetic diversity / Genetic Predisposition to Disease / Genetic research / Genetic variance / Genetic Variation / Genome-wide association studies / Genome-Wide Association Study / Genomes / Genomics / Haplotypes / Humanities and Social Sciences / Humans / Intelligence / Intelligence - genetics / Letter / Linkage Disequilibrium / Male / Medical research / Mental disorders / multidisciplinary / Multifactorial Inheritance - genetics / Mutation / Nervous system / Neural coding / Neurodevelopmental disorders / Neurodevelopmental Disorders - genetics / Parent-child relations / Parents / Patients / Phenotype / Proteins / Rare Diseases - genetics / Risk / Risk factors / Schizophrenia / Schizophrenia - genetics / Science / Science (multidisciplinary) / Weight