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Enhanced Cortisol Response to Stress in Children in Autism
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Journal Article
Enhanced Cortisol Response to Stress in Children in Autism
2012
Overview
Children with Autism often show difficulties in adapting to change. Previous studies of cortisol, a neurobiologic stress hormone reflecting hypothalamic–pituitary–adrenal (HPA) axis activity, in children with autism have demonstrated variable results. This study measured cortisol levels in children with and without Autism: (1) at rest; (2) in a novel environment; and (3) in response to a blood draw stressor. A significantly higher serum cortisol response was found in the group of children with autism. Analysis showed significantly higher peak cortisol levels and prolonged duration and recovery of cortisol elevation following the blood-stick stressor in children with autism. This study suggests increased reactivity of the HPA axis to stress and novel stimuli in children with autism.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Autism
/ Autistic Disorder - metabolism
/ Autistic Disorder - physiopathology
/ Behavioral Science and Psychology
/ Biological and medical sciences
/ Biology
/ Blood
/ Brain
/ Change
/ Child
/ Children
/ Cortisol
/ Etiology
/ Female
/ Females
/ Hormones
/ Humans
/ Hypothalamic-pituitary-adrenal axis
/ Hypothalamo-Hypophyseal System - physiopathology
/ Male
/ Males
/ Neurodevelopmental disorders
/ Pituitary-Adrenal System - physiopathology
/ Psychology. Psychoanalysis. Psychiatry
/ Serum
/ Steroids
/ Stimuli
/ Stress
/ Stress, Physiological - physiology
/ Stress, Psychological - metabolism
