Journal Article

Liver steatosis and dyslipidemia after HCV eradication by direct acting antiviral agents are synergistic risks of atherosclerosis

Nakamura, Akihisa, Izumi, Takaaki, Kawagishi, Naoki, Nakamura, Akinobu, Natsuizaka, Mitsuteru, Kimura, Megumi, Sakamoto, Naoya, Maehara, Osamu, Morikawa, Kenichi, Sho, Takuya, Umemura, Machiko, Kudo, Yusuke, Nakai, Masato, Miyoshi, Hideaki, Suzuki, Kazuharu, Suda, Goki, Ogawa, Koji, Nishida, Mutsumi, Ohara, Masatsugu

2018

Overview

We comprehensively analyzed how hepatitis C virus (HCV) eradication by interferon (IFN)-free direct-acting-antiviral-agents (DAAs) affects liver steatosis and atherogenic risk. Patients treated with IFN-free-DAAs who underwent transient elastography before and at 24-weeks post-treatment, including controlled attenuation parameter (CAP), and achieved sustained viral response (SVR) were enrolled. The association between changes in liver steatosis, lipid-metabolism, and genetic and clinical factors was analyzed. A total of 117 patients were included. The mean CAP and low-density lipoprotein cholesterol (LDL-C) levels were significantly elevated at SVR24. However, baseline LDL-C and CAP values were significantly negatively correlated with changes in these values after HCV eradication, indicating that in patients with high baseline values, the values generally decreased after HCV eradication. Mean small-dense LDL-C (sdLDL-C), which has greater atherogenic potential, was significantly elevated only in patients with both dyslipidemia (LDL-C >140 mg/dL) and liver steatosis (CAP >248 dB/m) at SVR24. Those patients had significant higher baseline BMI, LDL-C, and total-cholesterol levels. Generally, successful HCV eradication by IFN-free-DAAs decreases CAP and LDL-C in patients with high baseline values. However, elevated LDL-C was accompanied with elevated sdLDL-C only in patients with liver steatosis and dyslipidemia at SVR24; therefore, those patients may require closer monitoring.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adult / Aged / Antiviral agents / Antiviral Agents - adverse effects / Antiviral drugs / Arteriosclerosis / Atherosclerosis / Atherosclerosis - chemically induced / Atherosclerosis - epidemiology / Atherosclerosis - metabolism / Atherosclerosis - virology / Attenuation / Biology and life sciences / Biopsy / Body mass / Cardiovascular disease / Cholesterol / Cholesterol, LDL - metabolism / Complications and side effects / Diabetes / Dosage and administration / Dyslipidemia / Dyslipidemias - chemically induced / Dyslipidemias - epidemiology / Dyslipidemias - metabolism / Dyslipidemias - virology / Fatty liver / Fatty Liver - chemically induced / Fatty Liver - epidemiology / Fatty Liver - metabolism / Fatty Liver - virology / Female / Gastroenterology / Genotype & phenotype / Hepacivirus - drug effects / Hepacivirus - pathogenicity / Hepatitis / Hepatitis C / Hepatitis C virus / Hepatitis C, Chronic - complications / Hepatitis C, Chronic - drug therapy / Hepatitis C, Chronic - epidemiology / Hepatitis C, Chronic - virology / Hepatocellular carcinoma / Hepatology / Humans / Infections / Interferon / Laboratories / Lipid metabolism / Lipid Metabolism - drug effects / Lipids / Lipoproteins / Liver / Liver - drug effects / Liver - metabolism / Liver - virology / Liver cancer / Liver cirrhosis / Low density lipoprotein / Male / Medicine / Medicine and Health Sciences / Metabolic disorders / Metabolism / Middle Aged / Oxidation / Patients / Prevention / Proteins / Ribavirin - adverse effects / Risk Factors / Steatosis / Sustained Virologic Response / University graduates / Viruses