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Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson’s disease
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Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson’s disease
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Journal Article
Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson’s disease
2025
Overview
Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate its impact on memory and olfaction in PD. Thirty-nine PD patients awaiting evaluation for device-aided Parkinson therapy and 46 healthy controls (HC) underwent resting-state fMRI (rs-fMRI). PD patients also completed a memory and olfactory assessment. Co-activation pattern (CAP) analysis was performed on the rs-fMRI data. Our results demonstrated reduced activity in two hippocampal networks in PD: Network 1, incorporating the visual cortex, cerebellum, superior parietal lobule, and precuneus, and Network 5, incorporating parts of the central executive network. PD subgroups with reduced AHA in Network 1 and 5 performed significantly worse on tests of auditory-verbal short-term, long-term and recognition memory, as well as odor identification. In conclusion, within specific resting-state hippocampal networks, reduced AHA in PD is linked to poorer auditory-verbal memory and odor identification.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/617
/ 692/699
/ Aged
/ Asymmetric hippocampal activity
/ Co-activation pattern analysis
/ COVID-19
/ Female
/ Functional magnetic resonance imaging
/ Hippocampus - diagnostic imaging
/ Hippocampus - physiopathology
/ Humanities and Social Sciences
/ Humans
/ Male
/ Memory
/ Memory Disorders - diagnostic imaging
/ Memory Disorders - physiopathology
/ Odor
/ Odors
/ Olfaction Disorders - diagnostic imaging
/ Olfaction Disorders - etiology
/ Olfaction Disorders - physiopathology
/ Parkinson Disease - complications
/ Parkinson Disease - diagnostic imaging
/ Parkinson Disease - physiopathology
/ Rest
/ Science
