Asset Details
Do you wish to reserve the book?
Uncovering the prognostic implications and immunological roles of transmembrane protein 208 in bladder cancer by multi omics analysis and experimental verification
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Uncovering the prognostic implications and immunological roles of transmembrane protein 208 in bladder cancer by multi omics analysis and experimental verification
Do you wish to request the book?
Uncovering the prognostic implications and immunological roles of transmembrane protein 208 in bladder cancer by multi omics analysis and experimental verification
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Uncovering the prognostic implications and immunological roles of transmembrane protein 208 in bladder cancer by multi omics analysis and experimental verification
2025
Overview
In this study, we explored the role of transmembrane protein 208 (TMEM208), a transmembrane protein predominantly located in the endoplasmic reticulum, in bladder cancer (BLCA), where its absence is associated with developmental defects and cellular polarity disorders. Utilizing data from the TCGA database and 15 GEO datasets, we correlated TMEM208 expression with clinical features and employed the ComPPI website and Gene Set Enrichment Analysis (GSEA) to dissect its protein interactions and functional roles. Our analysis revealed that TMEM208 is significantly upregulated in BLCA, positively correlating with clinical severity and poor survival. GSEA indicated associations with oxidative phosphorylation, epithelial-mesenchymal transition, and stemness pathways. Immunoinfiltration analysis showed a predominantly positive correlation with immune cells, except for central memory T cells (Tcm) and T helper cells. Spatial transcriptomics and single-cell sequencing demonstrated TMEM208’s predominant expression in tumor cells and fibroblasts, aligning with tumor cell counts, and highlighting its crucial function within the tumor microenvironment. Cellular assays confirmed TMEM208’s ability to enhance BLCA cell proliferation, migration, and invasion. In conclusion, TMEM208’s overexpression in BLCA suggests its potential as an oncogenic factor, a prognostic indicator of poor outcomes, and a potential therapeutic target.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 692/53
/ Biomarkers, Tumor - genetics
/ Bladder
/ Cancer
/ Cells
/ Epithelial-Mesenchymal Transition - genetics
/ Female
/ Gene Expression Regulation, Neoplastic
/ Gene set enrichment analysis
/ Genomes
/ Genomics
/ Humanities and Social Sciences
/ Humans
/ Male
/ Membrane Proteins - genetics
/ Membrane Proteins - immunology
/ Membrane Proteins - metabolism
/ Proteins
/ Science
/ Software
/ Tumor Microenvironment - genetics
/ Tumor Microenvironment - immunology
/ Tumors
/ Urinary Bladder Neoplasms - genetics
/ Urinary Bladder Neoplasms - immunology
/ Urinary Bladder Neoplasms - metabolism
