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Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system
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Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system
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Journal Article
Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system
2019
Overview
Quantifying pathogen transmission in multi-host systems is difficult, as exemplified in bovine tuberculosis (bTB) systems, but is crucial for control. The agent of bTB,
, persists in cattle populations worldwide, often where potential wildlife reservoirs exist. However, the relative contribution of different host species to bTB persistence is generally unknown. In Britain, the role of badgers in infection persistence in cattle is highly contentious, despite decades of research and control efforts. We applied Bayesian phylogenetic and machine-learning approaches to bacterial genome data to quantify the roles of badgers and cattle in
infection dynamics in the presence of data biases. Our results suggest that transmission occurs more frequently from badgers to cattle than
(10.4x in the most likely model) and that within-species transmission occurs at higher rates than between-species transmission for both. If representative, our results suggest that control operations should target both cattle and badgers.
Publisher
eLife Science Publications, Ltd,eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
Subject
/ Animals
/ Animals, Wild - microbiology
/ Bacteria
/ badger
/ Cattle
/ Disease Reservoirs - microbiology
/ Epidemiology and Global Health
/ Genome, Bacterial - genetics
/ Genomes
/ Genomics
/ Microbiology and Infectious Disease
/ Mycobacterium bovis - classification
/ Mycobacterium bovis - genetics
/ Mycobacterium bovis - physiology
/ Parks
/ Species
/ Tuberculosis, Bovine - epidemiology
/ Tuberculosis, Bovine - microbiology
/ Tuberculosis, Bovine - transmission
/ Wildlife
