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Advances in Kruppel-like factor 5 as a transcription factor and its role in gynecological tumors (Review)
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Advances in Kruppel-like factor 5 as a transcription factor and its role in gynecological tumors (Review)
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Journal Article
Advances in Kruppel-like factor 5 as a transcription factor and its role in gynecological tumors (Review)
2026
Overview
Krüppel-like factor (KLF) 5 has garnered increasing interest in cancer research, as a zinc finger transcription factor integral to the regulation of cellular growth and division through gene transcription control. Initially investigated for its role in transcriptional regulation during normal tissue development, KLF5 was subsequently identified as a driver of cancer progression upon aberrant activation of its transcriptional activity. This functional dichotomy in transcriptional regulation has considerably enhanced the current understanding of the significance of KLF5 in human cancer. The dysregulation of such critical transcription factors has been shown to be closely linked with gynecological tumors, including cervical, ovarian and endometrial cancer. However, the specific regulatory mechanisms by which KLF5 influences the initiation and progression of gynecological tumors remains to be elucidated. The present review highlights the role of the KLF5 transcriptional regulatory network in the pathogenesis of gynecological tumors and its potential as a therapeutic target.
Publisher
D.A. Spandidos,Spandidos Publications,Spandidos Publications UK Ltd
Subject
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Cancer
/ Disease
/ Female
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Genital Neoplasms, Female - drug therapy
/ Genital Neoplasms, Female - genetics
/ Genital Neoplasms, Female - metabolism
/ Genital Neoplasms, Female - pathology
/ Humans
/ Kruppel-Like Transcription Factors - genetics
/ Kruppel-Like Transcription Factors - metabolism
/ Mutation
/ Proteins
/ Tumors
