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Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection
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Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection
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Journal Article
Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection
2011
Overview
Slowly clearing infections in the pleural space are a source of substantial morbidity. This study showed that instillation of recombinant DNase and tissue plasminogen activator (t-PA) is more effective than placebo in clearing radiographic pleural effusions.
Pleural infection affects more than 65,000 patients each year in the United States and the United Kingdom,
1
and the incidence is increasing in both countries — in both children
2
–
4
and adults.
5
,
6
The mortality rate from pleural infection is between 10% and 20%,
5
,
7
–
9
and drainage through a chest tube and administration of antibiotics fail in approximately one third of patients, who then require surgical drainage.
5
,
9
The median duration of the hospital stay for these patients is 12 to 15 days,
5
,
6
,
8
,
9
with 25% hospitalized for more than a month. Care of each patient costs . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Biofilms
/ Deoxyribonucleases - adverse effects
/ Deoxyribonucleases - therapeutic use
/ DNA
/ Effusion
/ Female
/ Fibrin
/ Fibrinolytic Agents - adverse effects
/ Fibrinolytic Agents - therapeutic use
/ Humans
/ Male
/ Patients
/ Pleural Diseases - diagnostic imaging
/ Pleural Diseases - drug therapy
/ Pleural Diseases - mortality
/ Pleural Effusion - diagnostic imaging
/ Pleural Effusion - drug therapy
/ Sepsis
/ Surgery
